Inhibition of Bcl-2 Sensitizes Mitochondrial Permeability Transition Pore (MPTP) Opening in Ischemia-Damaged Mitochondria

Qun Chen; Haishan Xu; Aijun Xu; Thomas Ross; Elizabeth Bowler; Ying Hu; Edward J. Lesnefsky

doi:10.1371/journal.pone.0118834

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Peer-reviewed

Research Article

Inhibition of Bcl-2 Sensitizes Mitochondrial Permeability Transition Pore (MPTP) Opening in Ischemia-Damaged Mitochondria

Qun Chen,

Affiliation Department of Medicine, Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Haishan Xu,

Affiliation Department of Medicine, Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Aijun Xu,

Affiliations Department of Medicine, Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Anesthesiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
⨯
Thomas Ross,

Affiliation Department of Medicine, Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Elizabeth Bowler,

Affiliations Department of Medicine, Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia, United States of America, University of the West of England, Bristol, United Kingdom
⨯
Ying Hu,

Affiliation Department of Medicine, Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Edward J. Lesnefsky

* E-mail: edward.lesnefsky@va.gov

Affiliations Department of Medicine, Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Medicine, Pauley Heart Center, Division of Biochemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America, McGuire Department of Veterans Affairs Medical Center, Richmond, Virginia, United States of America
⨯

Inhibition of Bcl-2 Sensitizes Mitochondrial Permeability Transition Pore (MPTP) Opening in Ischemia-Damaged Mitochondria

Qun Chen,
Haishan Xu,
Aijun Xu,
Thomas Ross,
Elizabeth Bowler,
Ying Hu,
Edward J. Lesnefsky

Published: March 10, 2015
https://doi.org/10.1371/journal.pone.0118834

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