Astragaloside IV Protects against Isoproterenol-Induced Cardiac Hypertrophy by Regulating NF-κB/PGC-1α Signaling Mediated Energy Biosynthesis

Suping Zhang; Futian Tang; Yuhong Yang; Meili Lu; Aina Luan; Jing Zhang; Juan Yang; Hongxin Wang

doi:10.1371/journal.pone.0118759

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Peer-reviewed

Research Article

Astragaloside IV Protects against Isoproterenol-Induced Cardiac Hypertrophy by Regulating NF-κB/PGC-1α Signaling Mediated Energy Biosynthesis

Suping Zhang ,

Contributed equally to this work with: Suping Zhang, Futian Tang

Affiliation Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Drug Research Institute, Liaoning Medical University, Jinzhou, Liaoning, P.R. China
⨯
Futian Tang ,

Contributed equally to this work with: Suping Zhang, Futian Tang

Affiliation Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Drug Research Institute, Liaoning Medical University, Jinzhou, Liaoning, P.R. China
⨯
Yuhong Yang,

Affiliation Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Drug Research Institute, Liaoning Medical University, Jinzhou, Liaoning, P.R. China
⨯
Meili Lu,

Affiliation Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Drug Research Institute, Liaoning Medical University, Jinzhou, Liaoning, P.R. China
⨯
Aina Luan,

Affiliation Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Drug Research Institute, Liaoning Medical University, Jinzhou, Liaoning, P.R. China
⨯
Jing Zhang,

Affiliation Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Drug Research Institute, Liaoning Medical University, Jinzhou, Liaoning, P.R. China
⨯
Juan Yang,

Affiliation Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Drug Research Institute, Liaoning Medical University, Jinzhou, Liaoning, P.R. China
⨯
Hongxin Wang

* E-mail: hongxinwang@lnmu.edu.cn

Affiliation Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Drug Research Institute, Liaoning Medical University, Jinzhou, Liaoning, P.R. China
⨯

Astragaloside IV Protects against Isoproterenol-Induced Cardiac Hypertrophy by Regulating NF-κB/PGC-1α Signaling Mediated Energy Biosynthesis

Suping Zhang,
Futian Tang,
Yuhong Yang,
Meili Lu,
Aina Luan,
Jing Zhang,
Juan Yang,
Hongxin Wang

Published: March 4, 2015
https://doi.org/10.1371/journal.pone.0118759

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