Constitutively Active Signaling by the G Protein βγ-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle Cells

Open Access

Peer-reviewed

Research Article

Aihua Hu,

Affiliation Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America
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Barry L. Diener,

Affiliation Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America
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Maureen B. Josephson,

Affiliation Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America
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Michael M. Grunstein

* E-mail: mgrun@med.upenn.edu

Affiliations Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
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Asthma
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Small interfering RNA
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Signal inhibition
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Phosphorylation
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Immunoblotting
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Transfection
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Co-immunoprecipitation
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G-protein signaling
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