Activin-A and Bmp4 Levels Modulate Cell Type Specification during CHIR-Induced Cardiomyogenesis

Min-Su Kim; Audrey Horst; Steven Blinka; Karl Stamm; Donna Mahnke; James Schuman; Rebekah Gundry; Aoy Tomita-Mitchell; John Lough

doi:10.1371/journal.pone.0118670

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Peer-reviewed

Research Article

Activin-A and Bmp4 Levels Modulate Cell Type Specification during CHIR-Induced Cardiomyogenesis

Min-Su Kim,

Affiliation Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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Audrey Horst,

Affiliation Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Steven Blinka,

Affiliation Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Karl Stamm,

Affiliation Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Donna Mahnke,

Affiliation Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
James Schuman,

Affiliation Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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Rebekah Gundry,

Affiliation Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Aoy Tomita-Mitchell,

Affiliations Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, The Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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John Lough

* E-mail: jlough@mcw.edu

Affiliations Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, The Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯

Activin-A and Bmp4 Levels Modulate Cell Type Specification during CHIR-Induced Cardiomyogenesis

Min-Su Kim,
Audrey Horst,
Steven Blinka,
Karl Stamm,
Donna Mahnke,
James Schuman,
Rebekah Gundry,
Aoy Tomita-Mitchell,
John Lough

Published: February 23, 2015
https://doi.org/10.1371/journal.pone.0118670

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Pluripotency
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Cell differentiation
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Insulin
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BMP signaling
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Cardiomyocytes
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Wnt signaling cascade
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