Validation of a Rapid and Sensitive LC-MS/MS Method for Determination of Exemestane and Its Metabolites, 17β-Hydroxyexemestane and 17β-Hydroxyexemestane-17-O-β-D-Glucuronide: Application to Human Pharmacokinetics Study

Ling-Zhi Wang; Sok-Hwei Goh; Andrea Li-Ann Wong; Win-Lwin Thuya; Jie-Ying Amelia Lau; Seow-Ching Wan; Soo-Chin Lee; Paul C. Ho; Boon-Cher Goh

doi:10.1371/journal.pone.0118553

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Research Article

Validation of a Rapid and Sensitive LC-MS/MS Method for Determination of Exemestane and Its Metabolites, 17β-Hydroxyexemestane and 17β-Hydroxyexemestane-17-O-β-D-Glucuronide: Application to Human Pharmacokinetics Study

Ling-Zhi Wang ,

* E-mail: csiwl@nus.edu.sg (LZW); phcgbc@nus.edu.sg (BCG)

Affiliations Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore, Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore 117599, Singapore
⨯
Sok-Hwei Goh,

Affiliation Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
⨯
Andrea Li-Ann Wong,

Affiliations Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore, Department of Haematology & Oncology, National University Health System, Singapore 119074, Singapore
⨯
Win-Lwin Thuya,

Affiliation Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore
⨯
Jie-Ying Amelia Lau,

Affiliation Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore
⨯
Seow-Ching Wan,

Affiliation Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore
⨯
Soo-Chin Lee,

Affiliations Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore, Department of Haematology & Oncology, National University Health System, Singapore 119074, Singapore
⨯
Paul C. Ho,

Affiliation Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
⨯
Boon-Cher Goh

* E-mail: csiwl@nus.edu.sg (LZW); phcgbc@nus.edu.sg (BCG)

Affiliations Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore, Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore 117599, Singapore, Department of Haematology & Oncology, National University Health System, Singapore 119074, Singapore
⨯

Validation of a Rapid and Sensitive LC-MS/MS Method for Determination of Exemestane and Its Metabolites, 17β-Hydroxyexemestane and 17β-Hydroxyexemestane-17-O-β-D-Glucuronide: Application to Human Pharmacokinetics Study

Ling-Zhi Wang,
Sok-Hwei Goh,
Andrea Li-Ann Wong,
Win-Lwin Thuya,
Jie-Ying Amelia Lau,
Seow-Ching Wan,
Soo-Chin Lee,
Paul C. Ho,
Boon-Cher Goh

Published: March 20, 2015
https://doi.org/10.1371/journal.pone.0118553

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