Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells

Dasa Medrikova; Tjeerd P. Sijmonsma; Katharina Sowodniok; David M. Richards; Michael Delacher; Carsten Sticht; Norbert Gretz; Tobias Schafmeier; Markus Feuerer; Stephan Herzig

doi:10.1371/journal.pone.0118534

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Peer-reviewed

Research Article

Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells

Dasa Medrikova,

Affiliation Joint Research Division Molecular Metabolic Control, German Cancer Research Center (DKFZ) Heidelberg, Center for Molecular Biology (ZMBH) and University Hospital, Heidelberg University, 69120, Heidelberg, Germany
⨯
Tjeerd P. Sijmonsma,

Affiliation Joint Research Division Molecular Metabolic Control, German Cancer Research Center (DKFZ) Heidelberg, Center for Molecular Biology (ZMBH) and University Hospital, Heidelberg University, 69120, Heidelberg, Germany
⨯
Katharina Sowodniok,

Affiliation Joint Research Division Molecular Metabolic Control, German Cancer Research Center (DKFZ) Heidelberg, Center for Molecular Biology (ZMBH) and University Hospital, Heidelberg University, 69120, Heidelberg, Germany
⨯
David M. Richards,

Affiliation Helmholtz Young Investigator Research Group Immune Tolerance, German Cancer Research Center (DKFZ) Heidelberg, 69120, Heidelberg, Germany
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Michael Delacher,

Affiliation Helmholtz Young Investigator Research Group Immune Tolerance, German Cancer Research Center (DKFZ) Heidelberg, 69120, Heidelberg, Germany
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Carsten Sticht,

Affiliation Center for Medical Research, University Clinics Mannheim, 68167, Mannheim, Germany
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Norbert Gretz,

Affiliation Center for Medical Research, University Clinics Mannheim, 68167, Mannheim, Germany
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Tobias Schafmeier,

Affiliations Joint Research Division Molecular Metabolic Control, German Cancer Research Center (DKFZ) Heidelberg, Center for Molecular Biology (ZMBH) and University Hospital, Heidelberg University, 69120, Heidelberg, Germany, Institute for Diabetes and Cancer IDC, Helmholtz Center Munich, 85764 Neuherberg, and Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, 69120, Heidelberg, Germany
⨯
Markus Feuerer ,

¶‡ These authors contributed equally to this work.

Affiliation Helmholtz Young Investigator Research Group Immune Tolerance, German Cancer Research Center (DKFZ) Heidelberg, 69120, Heidelberg, Germany
⨯
Stephan Herzig

* E-mail: s.herzig@dkfz.de

¶‡ These authors contributed equally to this work.

Affiliations Joint Research Division Molecular Metabolic Control, German Cancer Research Center (DKFZ) Heidelberg, Center for Molecular Biology (ZMBH) and University Hospital, Heidelberg University, 69120, Heidelberg, Germany, Institute for Diabetes and Cancer IDC, Helmholtz Center Munich, 85764 Neuherberg, and Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, 69120, Heidelberg, Germany
⨯

Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells

Dasa Medrikova,
Tjeerd P. Sijmonsma,
Katharina Sowodniok,
David M. Richards,
Michael Delacher,
Carsten Sticht,
Norbert Gretz,
Tobias Schafmeier,
Markus Feuerer,
Stephan Herzig

Published: February 25, 2015
https://doi.org/10.1371/journal.pone.0118534

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Brown adipose tissue
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Regulatory T cells
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Gene expression
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Macrophages
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Inflammation
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Cell metabolism
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Obesity
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