A Cell-Based Systems Biology Assessment of Human Blood to Monitor Immune Responses after Influenza Vaccination

Kristen L. Hoek; Parimal Samir; Leigh M. Howard; Xinnan Niu; Nripesh Prasad; Allison Galassie; Qi Liu; Tara M. Allos; Kyle A. Floyd; Yan Guo; Yu Shyr; Shawn E. Levy; Sebastian Joyce; Kathryn M. Edwards; Andrew J. Link

doi:10.1371/journal.pone.0118528

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Open Access

Peer-reviewed

Research Article

A Cell-Based Systems Biology Assessment of Human Blood to Monitor Immune Responses after Influenza Vaccination

Kristen L. Hoek,

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯
Parimal Samir,

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯
Leigh M. Howard,

Affiliation Vanderbilt Vaccine Research Program; Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯
Xinnan Niu,

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯
Nripesh Prasad,

Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, AL, 35806, United States of America
⨯
Allison Galassie,

Affiliation Department of Chemistry, Vanderbilt University, Nashville, TN, 27232, United States of America
⨯
Qi Liu,

Affiliation Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯
Tara M. Allos,

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
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Kyle A. Floyd,

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯
Yan Guo,

Affiliation Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯
Yu Shyr,

Affiliation Department of Cancer Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯
Shawn E. Levy,

Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, AL, 35806, United States of America
⨯
Sebastian Joyce,

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯
Kathryn M. Edwards ,

* E-mail: kathryn.edwards@vanderbilt.edu (KME); andrew.link@vanderbilt.edu (AJL)

Affiliation Vanderbilt Vaccine Research Program; Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯
Andrew J. Link

* E-mail: kathryn.edwards@vanderbilt.edu (KME); andrew.link@vanderbilt.edu (AJL)

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States of America
⨯

A Cell-Based Systems Biology Assessment of Human Blood to Monitor Immune Responses after Influenza Vaccination

Kristen L. Hoek,
Parimal Samir,
Leigh M. Howard,
Xinnan Niu,
Nripesh Prasad,
Allison Galassie,
Qi Liu,
Tara M. Allos,
Kyle A. Floyd,
Yan Guo

Published: February 23, 2015
https://doi.org/10.1371/journal.pone.0118528

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Vaccination and immunization
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Immune cells
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Protein expression
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B cells
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Blood
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Immune response
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Proteomic databases
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Transcriptome analysis
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