Patient-Specific Modeling of Regional Antibiotic Concentration Levels in Airways of Patients with Cystic Fibrosis: Are We Dosing High Enough?

Open Access

Peer-reviewed

Research Article

Aukje C. Bos,

Affiliations Department of Pediatric Pulmonology, Erasmus Medical Centre-Sophia Children’s Hospital, Rotterdam, the Netherlands, Department of Radiology, Erasmus Medical Centre, Rotterdam, the Netherlands
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Cedric van Holsbeke,

Affiliation FluidDA nv, Kontich, Belgium
⨯
Jan W. de Backer,

Affiliation FluidDA nv, Kontich, Belgium
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Mireille van Westreenen,

Affiliation Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, Rotterdam, the Netherlands
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Hettie M. Janssens,

Affiliation Department of Pediatric Pulmonology, Erasmus Medical Centre-Sophia Children’s Hospital, Rotterdam, the Netherlands
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Wim G. Vos,

Affiliation FluidDA nv, Kontich, Belgium
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Harm A. W. M. Tiddens

* E-mail: h.tiddens@erasmusmc.nl

Affiliations Department of Pediatric Pulmonology, Erasmus Medical Centre-Sophia Children’s Hospital, Rotterdam, the Netherlands, Department of Radiology, Erasmus Medical Centre, Rotterdam, the Netherlands
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Aerosols
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Antibiotics
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Breathing
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Inhalation
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Sputum
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Tidal volume
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Cystic fibrosis
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Pulmonary function
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