Gp78, an E3 Ubiquitin Ligase Acts as a Gatekeeper Suppressing Nonalcoholic Steatohepatitis (NASH) and Liver Cancer

Tianpeng Zhang; Dhong Hyo Kho; Ying Wang; Yosuke Harazono; Kosei Nakajima; Youming Xie; Avraham Raz

doi:10.1371/journal.pone.0118448

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Peer-reviewed

Research Article

Gp78, an E3 Ubiquitin Ligase Acts as a Gatekeeper Suppressing Nonalcoholic Steatohepatitis (NASH) and Liver Cancer

Tianpeng Zhang ,

Contributed equally to this work with: Tianpeng Zhang, Dhong Hyo Kho

Affiliation Departments of Oncology and Pathology, Wayne State University School of Medicine and the Karmanos Cancer Institute, Detroit, Michigan, United States of America
⨯
Dhong Hyo Kho ,

Contributed equally to this work with: Tianpeng Zhang, Dhong Hyo Kho

Affiliation Departments of Oncology and Pathology, Wayne State University School of Medicine and the Karmanos Cancer Institute, Detroit, Michigan, United States of America
⨯
Ying Wang,

Affiliation Departments of Oncology and Pathology, Wayne State University School of Medicine and the Karmanos Cancer Institute, Detroit, Michigan, United States of America
⨯
Yosuke Harazono,

Affiliation Departments of Oncology and Pathology, Wayne State University School of Medicine and the Karmanos Cancer Institute, Detroit, Michigan, United States of America
⨯
Kosei Nakajima,

Affiliation Departments of Oncology and Pathology, Wayne State University School of Medicine and the Karmanos Cancer Institute, Detroit, Michigan, United States of America
⨯
Youming Xie,

Affiliation Departments of Oncology and Pathology, Wayne State University School of Medicine and the Karmanos Cancer Institute, Detroit, Michigan, United States of America
⨯
Avraham Raz

* E-mail: raza@karmanos.org

Affiliation Departments of Oncology and Pathology, Wayne State University School of Medicine and the Karmanos Cancer Institute, Detroit, Michigan, United States of America
⨯

Gp78, an E3 Ubiquitin Ligase Acts as a Gatekeeper Suppressing Nonalcoholic Steatohepatitis (NASH) and Liver Cancer

Tianpeng Zhang,
Dhong Hyo Kho,
Ying Wang,
Yosuke Harazono,
Kosei Nakajima,
Youming Xie,
Avraham Raz

Published: March 19, 2015
https://doi.org/10.1371/journal.pone.0118448

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Fatty liver
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Immunoprecipitation
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Steatosis
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Endoplasmic reticulum
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