Global Analysis Reveals Families of Chemical Motifs Enriched for hERG Inhibitors

• Fang Du ,

  Current address: Covance Inc., Princeton, NJ 08540, United States of America

  ¶‡ These authors contributed equally to this work.

  Affiliation The Solomon H. Snyder Department of Neuroscience, High Throughput Biology Center and Johns Hopkins Ion Channel Center (JHICC), Johns Hopkins University, 733 North Broadway, Baltimore, MD 21205, United States of America

  ⨯
• Joseph J. Babcock ,

  Current address: Netflix Inc., Los Gatos, CA 95032, United States of America

  ¶‡ These authors contributed equally to this work.

  Affiliation The Solomon H. Snyder Department of Neuroscience, High Throughput Biology Center and Johns Hopkins Ion Channel Center (JHICC), Johns Hopkins University, 733 North Broadway, Baltimore, MD 21205, United States of America

  ⨯
• Haibo Yu,

  Current address: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

  Affiliation The Solomon H. Snyder Department of Neuroscience, High Throughput Biology Center and Johns Hopkins Ion Channel Center (JHICC), Johns Hopkins University, 733 North Broadway, Baltimore, MD 21205, United States of America

  ⨯
• Beiyan Zou,

  Current address: Molecular Devices LLC, Sunnyvale, CA 94089, United States of America

  Affiliation The Solomon H. Snyder Department of Neuroscience, High Throughput Biology Center and Johns Hopkins Ion Channel Center (JHICC), Johns Hopkins University, 733 North Broadway, Baltimore, MD 21205, United States of America

  ⨯
• Min Li

  * E-mail: min.x.li@gsk.com

  Current address: GlaxoSmithKline (GSK), King of Prussia, PA 19406, United States of America

  Affiliation The Solomon H. Snyder Department of Neuroscience, High Throughput Biology Center and Johns Hopkins Ion Channel Center (JHICC), Johns Hopkins University, 733 North Broadway, Baltimore, MD 21205, United States of America

  ⨯