Increased Risk of Genetic and Epigenetic Instability in Human Embryonic Stem Cells Associated with Specific Culture Conditions

• Ibon Garitaonandia ,

  Current address: Department of Neurogenetics, International Stem Cell Corporation, 2595 Jason Court, Oceanside, CA, 92056, United States of America

  ¶‡ These authors contributed equally to this work.

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Hadar Amir ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Department of Reproductive Medicine, UCSD Healthcare, 9500 Gilman Drive, Mail Code 0695, San Diego, CA 92093, United States of America

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• Francesca Sesillo Boscolo ,

  Current address: Sanford-Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, United States of America

  ¶‡ These authors contributed equally to this work.

  Affiliations Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America, Department of Reproductive Medicine, UCSD Healthcare, 9500 Gilman Drive, Mail Code 0695, San Diego, CA 92093, United States of America

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• Gerald K. Wambua,

  Current address: Department of Neurogenetics, International Stem Cell Corporation, 2595 Jason Court, Oceanside, CA, 92056, United States of America

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Heather L. Schultheisz,

  Current address: Quantitative PCR group, Life Technologies, 5791 Van Allen Way, Carlsbad, CA 92008, United States of America

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Karen Sabatini,

  Affiliations Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America, Department of Reproductive Medicine, UCSD Healthcare, 9500 Gilman Drive, Mail Code 0695, San Diego, CA 92093, United States of America

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• Robert Morey,

  Affiliations Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America, Department of Reproductive Medicine, UCSD Healthcare, 9500 Gilman Drive, Mail Code 0695, San Diego, CA 92093, United States of America

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• Shannon Waltz,

  Current address: FLIR Systems, 505 Coast Boulevard South, La Jolla, CA 92037, United States of America

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Yu-Chieh Wang,

  Current address: Department of Pharmaceutical Sciences, The University of North Texas Health Science Center, Fort Worth, Texas, United States of America

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Ha Tran,

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Trevor R. Leonardo,

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Kristopher Nazor,

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Ileana Slavin,

  Current address: Isis Pharmaceuticals, 2855 Gazelle Ct, Carlsbad, CA 92008, United States of America

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Candace Lynch,

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Yingchun Li,

  Affiliation Department of Pathology, UCSD Healthcare, 9500 Gilman Drive, Mail Code 0695, La Jolla, CA 92093-0612, United States of America

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• Ronald Coleman,

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• Irene Gallego Romero,

  Affiliation Department of Human Genetics, University of Chicago, 920 E 58th St, CLSC 317, Chicago, IL, 60637, United States of America

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• Gulsah Altun,

  Current address: Bioinformatics R&D, Life Technologies, Lincoln Center Dr, Foster City, CA, 94404, United States of America

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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• David Reynolds,

  Affiliation Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, Paul D. Coverdell Center for Biomedical and Health Sciences, University of Georgia, Athens, GA, 30602, United States of America

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• Stephen Dalton,

  Affiliation Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, Paul D. Coverdell Center for Biomedical and Health Sciences, University of Georgia, Athens, GA, 30602, United States of America

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• Mana Parast,

  Affiliation Department of Pathology, UCSD Healthcare, 9500 Gilman Drive, Mail Code 0695, La Jolla, CA 92093-0612, United States of America

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• Jeanne F. Loring ,

  * E-mail: llaurent@ucsd.edu (LCL); jloring@scripps.edu (JFL)

  Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America

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•  [ ... ],
• Louise C. Laurent

  * E-mail: llaurent@ucsd.edu (LCL); jloring@scripps.edu (JFL)

  Affiliations Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America, Department of Reproductive Medicine, UCSD Healthcare, 9500 Gilman Drive, Mail Code 0695, San Diego, CA 92093, United States of America

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