Violation of an Evolutionarily Conserved Immunoglobulin Diversity Gene Sequence Preference Promotes Production of dsDNA-Specific IgG Antibodies

• Aaron Silva-Sanchez ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Cun Ren Liu ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Andre M. Vale ,

  ¶‡ These authors contributed equally to this work.

  Affiliations Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Program in Immunobiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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• Mohamed Khass ,

  ¶‡ These authors contributed equally to this work.

  Affiliations Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Genetic Engineering Division, National Research Center of Egypt, Ad Doqi, Egypt

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• Pratibha Kapoor,

  Affiliation Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Ada Elgavish,

  Affiliation Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Ivaylo I. Ivanov,

  Current address: Department of Microbiology & Immunology, Columbia University, New York, New York, 10032, United States of America

  Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Gregory C. Ippolito,

  Current address: Department of Biosciences, University of Texas at Austin, Austin, Texas, 78712, United States of America

  Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Robert L. Schelonka,

  Current address: Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, 97239, United States of America

  Affiliation Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Trenton R. Schoeb,

  Affiliation Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Peter D. Burrows,

  Affiliations Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Harry W. Schroeder Jr.

  * E-mail: hwsj@uab.edu

  Affiliations Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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