Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha

Daniel Rycroft; Jane Sosabowski; Edward Coulstock; Marie Davies; John Morrey; Sarah Friel; Fiona Kelly; Robert Hamatake; Milan Ovečka; Rob Prince; Laura Goodall; Armin Sepp; Adam Walker

doi:10.1371/journal.pone.0117847

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Open Access

Peer-reviewed

Research Article

Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha

Daniel Rycroft,

Affiliation Biopharm Innovation Unit, Biopharm Research and Development, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Jane Sosabowski,

Affiliation Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⨯
Edward Coulstock,

Affiliation Biopharm Innovation Unit, Biopharm Research and Development, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Marie Davies,

Affiliation Biopharm Innovation Unit, Biopharm Research and Development, GlaxoSmithKline, Cambridge, United Kingdom
⨯
John Morrey,

Affiliation Institute for Antiviral Research, Utah State University, Logan, Utah, United States of America
⨯
Sarah Friel,

Affiliation Biopharm Innovation Unit, Biopharm Research and Development, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Fiona Kelly,

Affiliation Biopharm Translational Medicine, Biopharm R&D, GlaxoSmithKline, Stevenage, United Kingdom
⨯
Robert Hamatake,

Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America
⨯
Milan Ovečka,

Affiliation Biopharm Innovation Unit, Biopharm Research and Development, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Rob Prince,

Affiliation Biopharm Discovery, Biopharm R&D, GlaxoSmithKline, Stevenage, United Kingdom
⨯
Laura Goodall,

Affiliation Biopharm Innovation Unit, Biopharm Research and Development, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Armin Sepp,

Affiliation Biopharm Innovation Unit, Biopharm Research and Development, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Adam Walker

* E-mail: adam.z.walker@gsk.com

Current address: Clinical Unit Cambridge, GlaxoSmithKline, Cambridge, United Kingdom

Affiliation Biopharm Innovation Unit, Biopharm Research and Development, GlaxoSmithKline, Cambridge, United Kingdom
⨯

Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha

Daniel Rycroft,
Jane Sosabowski,
Edward Coulstock,
Marie Davies,
John Morrey,
Sarah Friel,
Fiona Kelly,
Robert Hamatake,
Milan Ovečka,
Rob Prince

Published: February 17, 2015
https://doi.org/10.1371/journal.pone.0117847

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