Cleavage of Host Cytokeratin-6 by Lysine-Specific Gingipain Induces Gingival Inflammation in Periodontitis Patients

Salunya Tancharoen; Takashi Matsuyama; Ko-ichi Kawahara; Kenji Tanaka; Lyang-Ja Lee; Miho Machigashira; Kazuyuki Noguchi; Takashi Ito; Takahisa Imamura; Jan Potempa; Kiyoshi Kikuchi; Ikuro Maruyama

doi:10.1371/journal.pone.0117775

Loading metrics

Open Access

Peer-reviewed

Research Article

Cleavage of Host Cytokeratin-6 by Lysine-Specific Gingipain Induces Gingival Inflammation in Periodontitis Patients

Salunya Tancharoen,

Affiliation Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
⨯
Takashi Matsuyama,

Affiliation Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Ko-ichi Kawahara,

Affiliation Laboratory of Functional Foods, Department of Biomedical Engineering, Osaka Institute of Technology, Osaka, Japan
⨯
Kenji Tanaka,

Affiliation Membrane Protein and Ligand Analysis Center, Protosera Inc., Amagasaki, Japan
⨯
Lyang-Ja Lee,

Affiliation Membrane Protein and Ligand Analysis Center, Protosera Inc., Amagasaki, Japan
⨯
Miho Machigashira,

Affiliation Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Kazuyuki Noguchi,

Affiliation Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Takashi Ito,

Affiliation Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan
⨯
Takahisa Imamura,

Affiliation Department of Molecular Pathology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Jan Potempa,

Affiliations Department of Periodontics, Endodontics and Dental Hygiene, University of Louisville School of Dentistry, Louisville, Kentucky, United States of America, Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland
⨯
Kiyoshi Kikuchi,

Affiliation Department of Physiology, Kurume University School of Medicine, Fukuoka, Japan
⨯
Ikuro Maruyama

* E-mail: rinken@m3.kufm.kagoshima-u.ac.jp

Affiliation Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan
⨯

Cleavage of Host Cytokeratin-6 by Lysine-Specific Gingipain Induces Gingival Inflammation in Periodontitis Patients

Salunya Tancharoen,
Takashi Matsuyama,
Ko-ichi Kawahara,
Kenji Tanaka,
Lyang-Ja Lee,
Miho Machigashira,
Kazuyuki Noguchi,
Takashi Ito,
Takahisa Imamura,
Jan Potempa

Published: February 17, 2015
https://doi.org/10.1371/journal.pone.0117775

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Keratins
Is the Subject Area "Keratins" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Epithelial cells
Is the Subject Area "Epithelial cells" applicable to this article?

Thanks for your feedback.
Fluorescence imaging
Is the Subject Area "Fluorescence imaging" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Cytoskeleton
Is the Subject Area "Cytoskeleton" applicable to this article?

Thanks for your feedback.
Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.