The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice

John D. Belcher; Chunsheng Chen; Julia Nguyen; Fuad Abdulla; Phong Nguyen; Minh Nguyen; Nicole M. Okeley; Dennis R. Benjamin; Peter D. Senter; Gregory M. Vercellotti

doi:10.1371/journal.pone.0117772

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Peer-reviewed

Research Article

The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice

John D. Belcher ,

* E-mail: belcher@umn.edu

Affiliation Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Minneapolis, Minnesota, United States of America
⨯
Chunsheng Chen,

Affiliation Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Minneapolis, Minnesota, United States of America
⨯
Julia Nguyen,

Affiliation Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Minneapolis, Minnesota, United States of America
⨯
Fuad Abdulla,

Affiliation Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Minneapolis, Minnesota, United States of America
⨯
Phong Nguyen,

Affiliation Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Minneapolis, Minnesota, United States of America
⨯
Minh Nguyen,

Affiliation Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Minneapolis, Minnesota, United States of America
⨯
Nicole M. Okeley,

Affiliation Seattle Genetics, Inc., Bothell, Washington, United States of America
⨯
Dennis R. Benjamin,

Affiliation Seattle Genetics, Inc., Bothell, Washington, United States of America
⨯
Peter D. Senter,

Affiliation Seattle Genetics, Inc., Bothell, Washington, United States of America
⨯
Gregory M. Vercellotti

Affiliation Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Minneapolis, Minnesota, United States of America
⨯

The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice

John D. Belcher,
Chunsheng Chen,
Julia Nguyen,
Fuad Abdulla,
Phong Nguyen,
Minh Nguyen,
Nicole M. Okeley,
Dennis R. Benjamin,
Peter D. Senter,
Gregory M. Vercellotti

Published: February 23, 2015
https://doi.org/10.1371/journal.pone.0117772

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