Prenatal Stress Down-Regulates Reelin Expression by Methylation of Its Promoter and Induces Adult Behavioral Impairments in Rats

• Ismael Palacios-García ,

  ¶‡ These authors contributed equally to this work.

  Affiliations Departamento de Psiquiatría, Escuela de Medicina, and Centro Interdisciplinario de Neurociencia, Pontificia Universidad Católica de Chile, Santiago, Chile, Laboratory of Cell and Neuronal Dynamics (Cenedyn), Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile

  ⨯
• Ariel Lara-Vásquez ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Departamento de Psiquiatría, Escuela de Medicina, and Centro Interdisciplinario de Neurociencia, Pontificia Universidad Católica de Chile, Santiago, Chile

  ⨯
• Juan F. Montiel,

  Affiliation Centro de Investigación Biomédica, Facultad de Medicina, Universidad Diego Portales, Santiago, Chile

  ⨯
• Gabriela F. Díaz-Véliz,

  Affiliation Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago, Chile

  ⨯
• Hugo Sepúlveda,

  Affiliation Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, and Fondo de Áreas Prioritarias (FONDAP) “Center for Genome Regulation”, Universidad Andrés Bello, Santiago, Chile

  ⨯
• Elías Utreras,

  Affiliation Laboratory of Cell and Neuronal Dynamics (Cenedyn), Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile

  ⨯
• Martín Montecino,

  Affiliation Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, and Fondo de Áreas Prioritarias (FONDAP) “Center for Genome Regulation”, Universidad Andrés Bello, Santiago, Chile

  ⨯
• Christian González-Billault ,

  * E-mail: chrgonza@uchile.cl (CGB); faboitiz@puc.cl (FA)

  Affiliation Laboratory of Cell and Neuronal Dynamics (Cenedyn), Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile

  ⨯
• Francisco Aboitiz

  * E-mail: chrgonza@uchile.cl (CGB); faboitiz@puc.cl (FA)

  Affiliation Departamento de Psiquiatría, Escuela de Medicina, and Centro Interdisciplinario de Neurociencia, Pontificia Universidad Católica de Chile, Santiago, Chile

  ⨯