Pre-Transplant Donor-Specific T-Cell Alloreactivity Is Strongly Associated with Early Acute Cellular Rejection in Kidney Transplant Recipients Not Receiving T-Cell Depleting Induction Therapy

Elena Crespo; Marc Lucia; Josep M. Cruzado; Sergio Luque; Edoardo Melilli; Anna Manonelles; Nuria Lloberas; Joan Torras; Josep M. Grinyó; Oriol Bestard

doi:10.1371/journal.pone.0117618

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Open Access

Peer-reviewed

Research Article

Pre-Transplant Donor-Specific T-Cell Alloreactivity Is Strongly Associated with Early Acute Cellular Rejection in Kidney Transplant Recipients Not Receiving T-Cell Depleting Induction Therapy

Elena Crespo,

Affiliation Experimental Nephrology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
⨯
Marc Lucia,

Affiliation Experimental Nephrology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
⨯
Josep M. Cruzado,

Affiliations Experimental Nephrology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, Renal Transplant Unit, Nephrology department, Bellvitge University Hospital, Barcelona, Spain
⨯
Sergio Luque,

Affiliation Experimental Nephrology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
⨯
Edoardo Melilli,

Affiliation Renal Transplant Unit, Nephrology department, Bellvitge University Hospital, Barcelona, Spain
⨯
Anna Manonelles,

Affiliations Experimental Nephrology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, Renal Transplant Unit, Nephrology department, Bellvitge University Hospital, Barcelona, Spain
⨯
Nuria Lloberas,

Affiliation Experimental Nephrology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
⨯
Joan Torras,

Affiliations Experimental Nephrology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, Renal Transplant Unit, Nephrology department, Bellvitge University Hospital, Barcelona, Spain
⨯
Josep M. Grinyó,

Affiliations Experimental Nephrology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, Renal Transplant Unit, Nephrology department, Bellvitge University Hospital, Barcelona, Spain
⨯
Oriol Bestard

* E-mail: obestard@bellvitgehospital.cat

Affiliations Experimental Nephrology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, Renal Transplant Unit, Nephrology department, Bellvitge University Hospital, Barcelona, Spain
⨯

Pre-Transplant Donor-Specific T-Cell Alloreactivity Is Strongly Associated with Early Acute Cellular Rejection in Kidney Transplant Recipients Not Receiving T-Cell Depleting Induction Therapy

Elena Crespo,
Marc Lucia,
Josep M. Cruzado,
Sergio Luque,
Edoardo Melilli,
Anna Manonelles,
Nuria Lloberas,
Joan Torras,
Josep M. Grinyó,
Oriol Bestard

Published: February 17, 2015
https://doi.org/10.1371/journal.pone.0117618

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T cells
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Renal transplantation
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Enzyme-linked immunoassays
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