The Co-Transplantation of Bone Marrow Derived Mesenchymal Stem Cells Reduced Inflammation in Intramuscular Islet Transplantation

Gumpei Yoshimatsu; Naoaki Sakata; Haruyuki Tsuchiya; Takashi Minowa; Taro Takemura; Hiromi Morita; Tatsuo Hata; Masahiko Fukase; Takeshi Aoki; Masaharu Ishida; Fuyuhiko Motoi; Takeshi Naitoh; Yu Katayose; Shinichi Egawa; Michiaki Unno

doi:10.1371/journal.pone.0117561

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Open Access

Peer-reviewed

Research Article

The Co-Transplantation of Bone Marrow Derived Mesenchymal Stem Cells Reduced Inflammation in Intramuscular Islet Transplantation

Gumpei Yoshimatsu,

Affiliation Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Naoaki Sakata ,

* E-mail: n-sakata@surg1.med.tohoku.ac.jp

Affiliation Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Haruyuki Tsuchiya,

Affiliation Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Takashi Minowa,

Affiliation Nanotechnology Innovation Station, National Institute for Materials Science, Tsukuba, Japan
⨯
Taro Takemura,

Affiliation Nanotechnology Innovation Station, National Institute for Materials Science, Tsukuba, Japan
⨯
Hiromi Morita,

Affiliation Nanotechnology Innovation Station, National Institute for Materials Science, Tsukuba, Japan
⨯
Tatsuo Hata,

Affiliation Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Masahiko Fukase,

Affiliation Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Takeshi Aoki,

Affiliation Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Masaharu Ishida,

Affiliation Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Fuyuhiko Motoi,

Affiliation Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Takeshi Naitoh,

Affiliation Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Yu Katayose,

Affiliations Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan, Division of Integrated Surgery and Oncology, Tohoku University Hospital, Sendai, Japan
⨯
Shinichi Egawa,

Affiliation Division of International Cooperation for Disaster Medicine, Tohoku University, Sendai, Japan
⨯
Michiaki Unno

Affiliation Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯

The Co-Transplantation of Bone Marrow Derived Mesenchymal Stem Cells Reduced Inflammation in Intramuscular Islet Transplantation

Gumpei Yoshimatsu,
Naoaki Sakata,
Haruyuki Tsuchiya,
Takashi Minowa,
Taro Takemura,
Hiromi Morita,
Tatsuo Hata,
Masahiko Fukase,
Takeshi Aoki,
Masaharu Ishida

Published: February 13, 2015
https://doi.org/10.1371/journal.pone.0117561

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Islet transplantation
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Mesenchymal stem cells
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Inflammation
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Gene expression
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Insulin
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Bone marrow transplantation
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