High-Affinity Accumulation of a Maytansinoid in Cells via Weak Tubulin Interaction

• Victor S. Goldmacher ,

  * E-mail: victor.goldmacher@immunogen.com

  Affiliation Department of Cell Biology, ImmunoGen, Inc., Waltham, Massachusetts, United States of America

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• Charlene A. Audette,

  Affiliation Department of Cell Biology, ImmunoGen, Inc., Waltham, Massachusetts, United States of America

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• Yinghua Guan,

  Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

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• Eriene-Heidi Sidhom,

  Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

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• Jagesh V. Shah,

  Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

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• Kathleen R. Whiteman,

  Affiliation Department of Cell Biology, ImmunoGen, Inc., Waltham, Massachusetts, United States of America

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• Yelena V. Kovtun

  Affiliation Department of Cell Biology, ImmunoGen, Inc., Waltham, Massachusetts, United States of America

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