PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo

• Michiaki Okuda ,

  * E-mail: jt-liaay@mail.doshisha.ac.jp

  Affiliations Pharma Eight Co., Ltd., Kyoto, Japan, Graduate School of Brain Science, Doshisha University, Kyoto, Japan

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• Ichiro Hijikuro,

  Affiliation ChemGenesis Inc., Tokyo, Japan

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• Yuki Fujita,

  Affiliations Pharma Eight Co., Ltd., Kyoto, Japan, Graduate School of Brain Science, Doshisha University, Kyoto, Japan

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• Xiaofeng Wu,

  Affiliation Key Lab of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

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• Shinichi Nakayama,

  Affiliation Pharma Eight Co., Ltd., Kyoto, Japan

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• Yoko Sakata,

  Affiliation Pharma Eight Co., Ltd., Kyoto, Japan

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• Yuji Noguchi,

  Affiliation Pharma Eight Co., Ltd., Kyoto, Japan

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• Makoto Ogo,

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Japan

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• Shigeru Akasofu,

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Japan

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• Yoshimasa Ito,

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Japan

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• Yoshiyuki Soeda,

  Affiliation Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan

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• Nobuhiko Tsuchiya,

  Affiliation Department of Biomolecular Engineering, Kyoto Institute of Technology, Kyoto, Japan

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• Naoki Tanaka,

  Affiliation Department of Biomolecular Engineering, Kyoto Institute of Technology, Kyoto, Japan

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• Takashi Takahashi,

  Affiliation Natural Product Chemistry & Pharmaceutical Research Center, Yokohama College of Pharmacy, Yokohama, Japan

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• Hachiro Sugimoto

  Affiliations Pharma Eight Co., Ltd., Kyoto, Japan, Graduate School of Brain Science, Doshisha University, Kyoto, Japan

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