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Open Access

Peer-reviewed

Research Article

Tanshinone IIA Inhibits HIF-1α and VEGF Expression in Breast Cancer Cells via mTOR/p70S6K/RPS6/4E-BP1 Signaling Pathway

Guobing Li,

Affiliation College of Pharmacy, Third Military Medical University, Chongqing, China
⨯
Changyu Shan,

Affiliation College of Pharmacy, Third Military Medical University, Chongqing, China
⨯
Lei Liu,

Affiliation College of Pharmacy, Third Military Medical University, Chongqing, China
⨯
Ting Zhou,

Affiliation College of Pharmacy, Third Military Medical University, Chongqing, China
⨯
Jing Zhou,

Affiliation College of Pharmacy, Third Military Medical University, Chongqing, China
⨯
Xiaoye Hu,

Affiliation College of Pharmacy, Third Military Medical University, Chongqing, China
⨯
Yibiao Chen,

Affiliation State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China
⨯
Hongjuan Cui,

Affiliation State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China
⨯
Ning Gao

* E-mail: gaoning59@163.com

Affiliation College of Pharmacy, Third Military Medical University, Chongqing, China
⨯

Tanshinone IIA Inhibits HIF-1α and VEGF Expression in Breast Cancer Cells via mTOR/p70S6K/RPS6/4E-BP1 Signaling Pathway

Guobing Li,
Changyu Shan,
Lei Liu,
Ting Zhou,
Jing Zhou,
Xiaoye Hu,
Yibiao Chen,
Hongjuan Cui,
Ning Gao

x

Published: February 6, 2015
https://doi.org/10.1371/journal.pone.0117440

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Breast cancer
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Hypoxia
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Cancer treatment
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Angiogenesis
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Mouse models
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Signal inhibition
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Cancers and neoplasms
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Enzyme-linked immunoassays
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