Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Growth Factor Receptor (EGFR) and c-Src: The Concept of Type III Combi-Targeting

Suman Rao; Anne-Laure Larroque-Lombard; Lisa Peyrard; Cédric Thauvin; Zakaria Rachid; Christopher Williams; Bertrand J. Jean-Claude

doi:10.1371/journal.pone.0117215

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Research Article

Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Growth Factor Receptor (EGFR) and c-Src: The Concept of Type III Combi-Targeting

Suman Rao,

Affiliation Cancer Drug Research Laboratory, Department of Medicine, Division of Medical Oncology, McGill University Health Center/Royal Victoria Hospital, 687 Pine Avenue West Rm M7.19, Montreal, Quebec, H3A 1A1 Canada
⨯
Anne-Laure Larroque-Lombard,

Affiliation Cancer Drug Research Laboratory, Department of Medicine, Division of Medical Oncology, McGill University Health Center/Royal Victoria Hospital, 687 Pine Avenue West Rm M7.19, Montreal, Quebec, H3A 1A1 Canada
⨯
Lisa Peyrard,

Affiliation Cancer Drug Research Laboratory, Department of Medicine, Division of Medical Oncology, McGill University Health Center/Royal Victoria Hospital, 687 Pine Avenue West Rm M7.19, Montreal, Quebec, H3A 1A1 Canada
⨯
Cédric Thauvin,

Affiliation Cancer Drug Research Laboratory, Department of Medicine, Division of Medical Oncology, McGill University Health Center/Royal Victoria Hospital, 687 Pine Avenue West Rm M7.19, Montreal, Quebec, H3A 1A1 Canada
⨯
Zakaria Rachid,

Affiliation Cancer Drug Research Laboratory, Department of Medicine, Division of Medical Oncology, McGill University Health Center/Royal Victoria Hospital, 687 Pine Avenue West Rm M7.19, Montreal, Quebec, H3A 1A1 Canada
⨯
Christopher Williams,

Affiliation Chemical Computing Group Inc., 1010 Sherbooke St. West, Suite #910, Montreal, QC, H3A 2R7 Canada
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Bertrand J. Jean-Claude

* E-mail: bertrandj.jean-claude@mcgill.ca

Affiliation Cancer Drug Research Laboratory, Department of Medicine, Division of Medical Oncology, McGill University Health Center/Royal Victoria Hospital, 687 Pine Avenue West Rm M7.19, Montreal, Quebec, H3A 1A1 Canada
⨯

Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Growth Factor Receptor (EGFR) and c-Src: The Concept of Type III Combi-Targeting

Suman Rao,
Anne-Laure Larroque-Lombard,
Lisa Peyrard,
Cédric Thauvin,
Zakaria Rachid,
Christopher Williams,
Bertrand J. Jean-Claude

Published: February 6, 2015
https://doi.org/10.1371/journal.pone.0117215

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