The Extracellular Loop 2 (ECL2) of the Human Histamine H4 Receptor Substantially Contributes to Ligand Binding and Constitutive Activity

Open Access

Peer-reviewed

Research Article

The Extracellular Loop 2 (ECL2) of the Human Histamine H₄ Receptor Substantially Contributes to Ligand Binding and Constitutive Activity

David Wifling,

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany
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Günther Bernhardt,

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany
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Stefan Dove,

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany
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Armin Buschauer

* E-mail: armin.buschauer@chemie.uni-regensburg.de

Affiliation Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry II, University of Regensburg, Regensburg, Germany
⨯

Histamine
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G protein coupled receptors
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Cell binding assay
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Partial agonists
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Phenylalanine
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Receptor binding assays
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Disulfide bonds
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Insects
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