The C-Type Lectin Receptor Mincle Binds to Streptococcus pneumoniae but Plays a Limited Role in the Anti-Pneumococcal Innate Immune Response

Anne Rabes; Stephanie Zimmermann; Katrin Reppe; Roland Lang; Peter H. Seeberger; Norbert Suttorp; Martin Witzenrath; Bernd Lepenies; Bastian Opitz

doi:10.1371/journal.pone.0117022

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Open Access

Peer-reviewed

Research Article

The C-Type Lectin Receptor Mincle Binds to Streptococcus pneumoniae but Plays a Limited Role in the Anti-Pneumococcal Innate Immune Response

Anne Rabes ,

¶‡ These authors are first authors for this work.

Affiliation Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany
⨯
Stephanie Zimmermann ,

¶‡ These authors are first authors for this work.

Affiliations Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Potsdam, Germany, Freie Universität Berlin, Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Berlin, Germany
⨯
Katrin Reppe,

Affiliation Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany
⨯
Roland Lang,

Affiliation Institute for Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, Erlangen, Germany
⨯
Peter H. Seeberger,

Affiliation Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Potsdam, Germany
⨯
Norbert Suttorp,

Affiliation Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany
⨯
Martin Witzenrath,

Affiliation Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany
⨯
Bernd Lepenies ,

Contributed equally to this work with: Bernd Lepenies, Bastian Opitz

* E-mail: bastian.opitz@charite.de (BO); bernd.lepenies@mpikg.mpg.de (BL)

Affiliations Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Potsdam, Germany, Freie Universität Berlin, Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Berlin, Germany
⨯
Bastian Opitz

Contributed equally to this work with: Bernd Lepenies, Bastian Opitz

* E-mail: bastian.opitz@charite.de (BO); bernd.lepenies@mpikg.mpg.de (BL)

Affiliation Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany
⨯

The C-Type Lectin Receptor Mincle Binds to Streptococcus pneumoniae but Plays a Limited Role in the Anti-Pneumococcal Innate Immune Response

Anne Rabes,
Stephanie Zimmermann,
Katrin Reppe,
Roland Lang,
Peter H. Seeberger,
Norbert Suttorp,
Martin Witzenrath,
Bernd Lepenies,
Bastian Opitz

Published: February 6, 2015
https://doi.org/10.1371/journal.pone.0117022

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Binding analysis
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Flow cytometry
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Immune response
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Lectins
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