Methamphetamine Accelerates Cellular Senescence through Stimulation of De Novo Ceramide Biosynthesis

• Giuseppe Astarita ,

  Current address: Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, United States of America; Health Sciences, Waters Corporation, Milford, Massachusetts, United States of America

  ¶‡ These authors contributed equally to this work.

  Affiliation Department of Pharmacology, University of California Irvine, Irvine, California, United States of America

  ⨯
• Agnesa Avanesian ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Department of Pharmacology, University of California Irvine, Irvine, California, United States of America

  ⨯
• Benedetto Grimaldi ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Drug Discovery and Development, Italian Institute of Technology, Genoa, Italy

  ⨯
• Natalia Realini ,

  ¶‡ These authors contributed equally to this work.

  Affiliation Drug Discovery and Development, Italian Institute of Technology, Genoa, Italy

  ⨯
• Zuzana Justinova,

  Affiliations Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Baltimore, Maryland, United States of America, Departement of Psychiatry, MPRC, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Leight V. Panlilio,

  Affiliation Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Baltimore, Maryland, United States of America

  ⨯
• Abdul Basit,

  Affiliation Drug Discovery and Development, Italian Institute of Technology, Genoa, Italy

  ⨯
• Steven R. Goldberg †,

  † Deceased.

  Affiliation Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Baltimore, Maryland, United States of America

  ⨯
• Daniele Piomelli

  * E-mail: piomelli@uci.edu

  Affiliations Drug Discovery and Development, Italian Institute of Technology, Genoa, Italy, Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America

  ⨯