The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia

• Xiqun Chen ,

  * E-mail: xchen17@mgh.harvard.edu (XC); AKAZANTSEV@mgh.harvard.edu (AGK)

  Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, United States of America

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• Pauline Wales,

  Affiliation Department of NeuroDegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Goettingen, Waldweg 33, 37073, Goettingen, Germany

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• Luisa Quinti,

  Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, United States of America

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• Fuxing Zuo,

  Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, United States of America

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• Sébastien Moniot,

  Affiliation Department of Biochemistry, University of Bayreuth, Universitaetsstrasse 30, 95447, Bayreuth, Germany

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• Fanny Herisson,

  Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, United States of America

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• Nazifa Abdul Rauf,

  Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, United States of America

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• Hua Wang,

  Affiliation Department of Chemistry, Department of Molecular Bioscience, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois, 60208-3113, United States of America

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• Richard B. Silverman,

  Affiliation Department of Chemistry, Department of Molecular Bioscience, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois, 60208-3113, United States of America

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• Cenk Ayata,

  Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, United States of America

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• Michelle M. Maxwell,

  Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, United States of America

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• Clemens Steegborn,

  Affiliation Department of Biochemistry, University of Bayreuth, Universitaetsstrasse 30, 95447, Bayreuth, Germany

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• Michael A. Schwarzschild,

  Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, United States of America

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• Tiago F. Outeiro,

  Affiliation Department of NeuroDegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Goettingen, Waldweg 33, 37073, Goettingen, Germany

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• Aleksey G. Kazantsev

  * E-mail: xchen17@mgh.harvard.edu (XC); AKAZANTSEV@mgh.harvard.edu (AGK)

  Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, United States of America

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