CHOPER Filters Enable Rare Mutation Detection in Complex Mutagenesis Populations by Next-Generation Sequencing

• Faezeh Salehi ,

  * E-mail: ssalehia@uci.edu (FS); pkaiser@uci.edu (PK)

  ¶‡ FS and RB contributed equally to this work. PK and RHL also contributed equally to this work.

  Affiliations Department of Computer Science, University of California Irvine, Irvine, CA, 92697, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, CA, 92697, United States of America

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• Roberta Baronio ,

  ¶‡ FS and RB contributed equally to this work. PK and RHL also contributed equally to this work.

  Affiliations Department of Biological Chemistry, University of California Irvine, Irvine, CA, 92697, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, CA, 92697, United States of America

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• Ryan Idrogo-Lam,

  Affiliation Department of Computer Science, University of California Irvine, Irvine, CA, 92697, United States of America

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• Huy Vu,

  Affiliation Department of Computer Science, University of California Irvine, Irvine, CA, 92697, United States of America

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• Linda V. Hall,

  Affiliations Department of Biological Chemistry, University of California Irvine, Irvine, CA, 92697, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, CA, 92697, United States of America

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• Peter Kaiser ,

  * E-mail: ssalehia@uci.edu (FS); pkaiser@uci.edu (PK)

  ¶‡ FS and RB contributed equally to this work. PK and RHL also contributed equally to this work.

  Affiliations Department of Biological Chemistry, University of California Irvine, Irvine, CA, 92697, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, CA, 92697, United States of America, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, United States of America

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• Richard H. Lathrop

  ¶‡ FS and RB contributed equally to this work. PK and RHL also contributed equally to this work.

  Affiliations Department of Computer Science, University of California Irvine, Irvine, CA, 92697, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, CA, 92697, United States of America, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, 92697, United States of America

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