Undifferentiated Bronchial Fibroblasts Derived from Asthmatic Patients Display Higher Elastic Modulus than Their Non-Asthmatic Counterparts

Michal Sarna; Katarzyna A. Wojcik; Pawel Hermanowicz; Dawid Wnuk; Kvetoslava Burda; Marek Sanak; Jarosław Czyż; Marta Michalik

doi:10.1371/journal.pone.0116840

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Peer-reviewed

Research Article

Undifferentiated Bronchial Fibroblasts Derived from Asthmatic Patients Display Higher Elastic Modulus than Their Non-Asthmatic Counterparts

Michal Sarna ,

* E-mail: michal.sarna@fis.agh.edu.pl (M. Sarna); marta.michalik@uj.edu.pl (MM)

Affiliation Department of Medical Physics and Biophysics, Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland
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Katarzyna A. Wojcik,

Affiliations Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland, Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland
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Pawel Hermanowicz,

Affiliation Department of Plant Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
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Dawid Wnuk,

Affiliation Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
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Kvetoslava Burda,

Affiliation Department of Medical Physics and Biophysics, Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland
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Marek Sanak,

Affiliation Laboratory of Molecular Biology and Clinical Genetics, Medical College, Jagiellonian University, Krakow, Poland
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Jarosław Czyż,

Affiliation Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
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Marta Michalik

* E-mail: michal.sarna@fis.agh.edu.pl (M. Sarna); marta.michalik@uj.edu.pl (MM)

Affiliation Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
⨯

Undifferentiated Bronchial Fibroblasts Derived from Asthmatic Patients Display Higher Elastic Modulus than Their Non-Asthmatic Counterparts

Michal Sarna,
Katarzyna A. Wojcik,
Pawel Hermanowicz,
Dawid Wnuk,
Kvetoslava Burda,
Marek Sanak,
Jarosław Czyż,
Marta Michalik

Published: February 13, 2015
https://doi.org/10.1371/journal.pone.0116840

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Asthma
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Fibroblasts
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Actins
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Atomic force microscopy
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Cytoskeleton
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Muscle contraction
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Bronchi
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Mechanical properties
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