Antagonistic Antiviral Activity between IFN-Lambda and IFN-Alpha against Lethal Crimean-Congo Hemorrhagic Fever Virus In Vitro

Licia Bordi; Eleonora Lalle; Claudia Caglioti; Damiano Travaglini; Daniele Lapa; Patrizia Marsella; Serena Quartu; Zoltan Kis; Kevin K. Arien; Hartwig P. Huemer; Silvia Meschi; Giuseppe Ippolito; Antonino Di Caro; Maria R. Capobianchi; Concetta Castilletti

doi:10.1371/journal.pone.0116816

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Peer-reviewed

Research Article

Antagonistic Antiviral Activity between IFN-Lambda and IFN-Alpha against Lethal Crimean-Congo Hemorrhagic Fever Virus In Vitro

Licia Bordi ,

¶‡ These authors contributed equally to this work.

Affiliation Laboratory of Virology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Eleonora Lalle ,

¶‡ These authors contributed equally to this work.

Affiliation Laboratory of Virology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Claudia Caglioti,

Affiliation Laboratory of Virology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Damiano Travaglini,

Affiliation Laboratory of Virology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Daniele Lapa,

Affiliation Laboratory of Virology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Patrizia Marsella,

Affiliation Laboratory of Virology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Serena Quartu,

Affiliation Laboratory of Virology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Zoltan Kis,

Affiliation Division of Virology, National Center for Epidemiology, Budapest, Hungary
⨯
Kevin K. Arien,

Affiliation Unit of Virology, Institute of Tropical Medicine, Antwerp, Belgium
⨯
Hartwig P. Huemer,

Affiliation Department of Hygiene, Microbiology & Social Medicine, Medical University Innsbruck, Innsbruck, Austria
⨯
Silvia Meschi,

Affiliation Laboratory of Virology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Giuseppe Ippolito,

Affiliation Scientific Direction, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Antonino Di Caro,

Affiliation Laboratory of Microbiology and Biorepository, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Maria R. Capobianchi ,

* E-mail: maria.capobianchi@inmi.it

Affiliation Laboratory of Virology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯
Concetta Castilletti

Affiliation Laboratory of Virology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy
⨯

Antagonistic Antiviral Activity between IFN-Lambda and IFN-Alpha against Lethal Crimean-Congo Hemorrhagic Fever Virus In Vitro

Licia Bordi,
Eleonora Lalle,
Claudia Caglioti,
Damiano Travaglini,
Daniele Lapa,
Patrizia Marsella,
Serena Quartu,
Zoltan Kis,
Kevin K. Arien,
Hartwig P. Huemer

Published: February 18, 2015
https://doi.org/10.1371/journal.pone.0116816

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