Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis

Sahar Pourhoseini; Ratanesh Kumar Seth; Suvarthi Das; Diptadip Dattaroy; Maria B. Kadiiska; Guanhua Xie; Gregory A. Michelotti; Mitzi Nagarkatti; Anna Mae Diehl; Saurabh Chatterjee

doi:10.1371/journal.pone.0116780

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Open Access

Peer-reviewed

Research Article

Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis

Sahar Pourhoseini ,

¶‡ SP and RKS contributed equally to this work.

Affiliation Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, 29208, United States of America
⨯
Ratanesh Kumar Seth ,

¶‡ SP and RKS contributed equally to this work.

Affiliation Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, 29208, United States of America
⨯
Suvarthi Das,

Affiliation Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, 29208, United States of America
⨯
Diptadip Dattaroy,

Affiliation Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, 29208, United States of America
⨯
Maria B. Kadiiska,

Affiliation Free Radical Metabolism Group, Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, United States of America
⨯
Guanhua Xie,

Affiliation Division of Gastroenterology, Duke University, Durham, NC, 27707, United States of America
⨯
Gregory A. Michelotti,

Affiliation Division of Gastroenterology, Duke University, Durham, NC, 27707, United States of America
⨯
Mitzi Nagarkatti,

Affiliation Dept. of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, 29209, United States of America
⨯
Anna Mae Diehl,

Affiliation Division of Gastroenterology, Duke University, Durham, NC, 27707, United States of America
⨯
Saurabh Chatterjee

* E-mail: schatt@mailbox.sc.edu

Affiliation Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, 29208, United States of America
⨯

Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis

Sahar Pourhoseini,
Ratanesh Kumar Seth,
Suvarthi Das,
Diptadip Dattaroy,
Maria B. Kadiiska,
Guanhua Xie,
Gregory A. Michelotti,
Mitzi Nagarkatti,
Anna Mae Diehl,
Saurabh Chatterjee

Published: February 6, 2015
https://doi.org/10.1371/journal.pone.0116780

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