In-Vivo Nonlinear Optical Microscopy (NLOM) of Epithelial-Connective Tissue Interface (ECTI) Reveals Quantitative Measures of Neoplasia in Hamster Oral Mucosa

Rahul Pal; Jinping Yang; Daniel Ortiz; Suimin Qiu; Vicente Resto; Susan McCammon; Gracie Vargas

doi:10.1371/journal.pone.0116754

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Peer-reviewed

Research Article

In-Vivo Nonlinear Optical Microscopy (NLOM) of Epithelial-Connective Tissue Interface (ECTI) Reveals Quantitative Measures of Neoplasia in Hamster Oral Mucosa

Rahul Pal ,

* E-mail: rapal@utmb.edu

Affiliations Center for Biomedical Engineering, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America, Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America
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Jinping Yang,

Affiliation Center for Biomedical Engineering, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America
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Daniel Ortiz,

Affiliation Department of Radiology, Eastern Virginia Medical School, Norfolk, VA, 23507, United States of America
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Suimin Qiu,

Affiliations Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America, Center for Cancers of the Head and Neck, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America
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Vicente Resto,

Affiliations Department of Otolaryngology, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America, Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America, Center for Cancers of the Head and Neck, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America
⨯
Susan McCammon,

Affiliations Department of Otolaryngology, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America, Center for Cancers of the Head and Neck, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America
⨯
Gracie Vargas

Affiliations Center for Biomedical Engineering, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America, Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America, Center for Cancers of the Head and Neck, The University of Texas Medical Branch, Galveston, TX, 77555, United States of America
⨯

In-Vivo Nonlinear Optical Microscopy (NLOM) of Epithelial-Connective Tissue Interface (ECTI) Reveals Quantitative Measures of Neoplasia in Hamster Oral Mucosa

Rahul Pal,
Jinping Yang,
Daniel Ortiz,
Suimin Qiu,
Vicente Resto,
Susan McCammon,
Gracie Vargas

Published: January 29, 2015
https://doi.org/10.1371/journal.pone.0116754

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Dysplasia
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Epithelium
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Histology
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Hamsters
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In vivo imaging
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Extracellular matrix
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Neoplastic transformation
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Cancers and neoplasms
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