Interaction between Calpain-1 and HSP90: New Insights into the Regulation of Localization and Activity of the Protease

Monica Averna; Roberta De Tullio; Marco Pedrazzi; Margherita Bavestrello; Matteo Pellegrini; Franca Salamino; Sandro Pontremoli; Edon Melloni

doi:10.1371/journal.pone.0116738

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Open Access

Peer-reviewed

Research Article

Interaction between Calpain-1 and HSP90: New Insights into the Regulation of Localization and Activity of the Protease

Monica Averna ,

* E-mail: monica.averna@unige.it

Affiliation Department of Experimental Medicine (DIMES)—Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, 1–16132 Genoa, Italy
⨯
Roberta De Tullio,

Affiliation Department of Experimental Medicine (DIMES)—Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, 1–16132 Genoa, Italy
⨯
Marco Pedrazzi,

Affiliation Department of Experimental Medicine (DIMES)—Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, 1–16132 Genoa, Italy
⨯
Margherita Bavestrello,

Affiliation Department of Experimental Medicine (DIMES)—Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, 1–16132 Genoa, Italy
⨯
Matteo Pellegrini,

Affiliation Department of Experimental Medicine (DIMES)—Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, 1–16132 Genoa, Italy
⨯
Franca Salamino,

Affiliation Department of Experimental Medicine (DIMES)—Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, 1–16132 Genoa, Italy
⨯
Sandro Pontremoli,

Affiliation Department of Experimental Medicine (DIMES)—Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, 1–16132 Genoa, Italy
⨯
Edon Melloni

Affiliation Department of Experimental Medicine (DIMES)—Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV, 1–16132 Genoa, Italy
⨯

Interaction between Calpain-1 and HSP90: New Insights into the Regulation of Localization and Activity of the Protease

Monica Averna,
Roberta De Tullio,
Marco Pedrazzi,
Margherita Bavestrello,
Matteo Pellegrini,
Franca Salamino,
Sandro Pontremoli,
Edon Melloni

Published: January 9, 2015
https://doi.org/10.1371/journal.pone.0116738

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Immunoprecipitation
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Proteases
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Immunoblotting
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Arithmetic
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Cloning
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Cytosol
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Protein interactions
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Cell physiology
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