Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle

Harumasa Nakazawa; Marina Yamada; Tomokazu Tanaka; Joshua Kramer; Yong-Ming Yu; Alan J. Fischman; J. A. Jeevendra Martyn; Ronald G. Tompkins; Masao Kaneki

doi:10.1371/journal.pone.0116633

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Peer-reviewed

Research Article

Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle

Harumasa Nakazawa ,

Contributed equally to this work with: Harumasa Nakazawa, Marina Yamada

Affiliation Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Marina Yamada ,

Contributed equally to this work with: Harumasa Nakazawa, Marina Yamada

Affiliations Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America, Shriners Hospitals for Children, Boston, Massachusetts, United States of America
⨯
Tomokazu Tanaka,

Affiliation Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Joshua Kramer,

Affiliation Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yong-Ming Yu,

Affiliations Shriners Hospitals for Children, Boston, Massachusetts, United States of America, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Alan J. Fischman,

Affiliation Shriners Hospitals for Children, Boston, Massachusetts, United States of America
⨯
J. A. Jeevendra Martyn,

Affiliations Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America, Shriners Hospitals for Children, Boston, Massachusetts, United States of America
⨯
Ronald G. Tompkins,

Affiliations Shriners Hospitals for Children, Boston, Massachusetts, United States of America, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Masao Kaneki

* E-mail: mkaneki@helix.mgh.harvard.edu

Affiliations Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America, Shriners Hospitals for Children, Boston, Massachusetts, United States of America
⨯

Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle

Harumasa Nakazawa,
Marina Yamada,
Tomokazu Tanaka,
Joshua Kramer,
Yong-Ming Yu,
Alan J. Fischman,
J. A. Jeevendra Martyn,
Ronald G. Tompkins,
Masao Kaneki

Published: January 16, 2015
https://doi.org/10.1371/journal.pone.0116633

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Skeletal muscles
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Inflammation
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Protein expression
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Insulin resistance
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Insulin
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Farnesylation
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Burns
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Protein metabolism
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