SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation

Tomohisa Hayakawa; Mika Iwai; Satoshi Aoki; Koichi Takimoto; Mitsuo Maruyama; Wakako Maruyama; Noboru Motoyama

doi:10.1371/journal.pone.0116480

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Open Access

Peer-reviewed

Research Article

SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation

Tomohisa Hayakawa,

Affiliations Department of Cognitive Brain Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan, Department of Aging Research, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
⨯
Mika Iwai,

Current address: Division of Molecular Carcinogenesis, Center of Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

Affiliation Department of Cognitive Brain Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
⨯
Satoshi Aoki,

Affiliations Department of Cognitive Brain Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan, Department of Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata, Japan
⨯
Koichi Takimoto,

Affiliation Department of Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata, Japan
⨯
Mitsuo Maruyama,

Affiliations Department of Aging Research, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan, Department of Mechanism of Aging, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
⨯
Wakako Maruyama,

Affiliation Department of Cognitive Brain Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
⨯
Noboru Motoyama

* E-mail: motoyama@ncgg.go.jp

Affiliations Department of Cognitive Brain Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan, Department of Aging Research, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
⨯

SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation

Tomohisa Hayakawa,
Mika Iwai,
Satoshi Aoki,
Koichi Takimoto,
Mitsuo Maruyama,
Wakako Maruyama,
Noboru Motoyama

Published: January 30, 2015
https://doi.org/10.1371/journal.pone.0116480

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Senescence
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Promoter regions
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Gene expression
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DNA damage
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Histones
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