Controlling Immune Rejection Is a Fail-Safe System against Potential Tumorigenicity after Human iPSC-Derived Neural Stem Cell Transplantation

Go Itakura; Yoshiomi Kobayashi; Soraya Nishimura; Hiroki Iwai; Morito Takano; Akio Iwanami; Yoshiaki Toyama; Hideyuki Okano; Masaya Nakamura

doi:10.1371/journal.pone.0116413

Loading metrics

Open Access

Peer-reviewed

Research Article

Controlling Immune Rejection Is a Fail-Safe System against Potential Tumorigenicity after Human iPSC-Derived Neural Stem Cell Transplantation

Go Itakura,

Affiliations Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan, Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
⨯
Yoshiomi Kobayashi,

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
⨯
Soraya Nishimura,

Affiliations Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan, Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
⨯
Hiroki Iwai,

Affiliations Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan, Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
⨯
Morito Takano,

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
⨯
Akio Iwanami,

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
⨯
Yoshiaki Toyama,

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
⨯
Hideyuki Okano ,

* E-mail: hidokano@a2.keio.jp (HO); masa@a8.keio.jp (MN)

Affiliation Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
⨯
Masaya Nakamura

* E-mail: hidokano@a2.keio.jp (HO); masa@a8.keio.jp (MN)

Affiliation Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
⨯

Controlling Immune Rejection Is a Fail-Safe System against Potential Tumorigenicity after Human iPSC-Derived Neural Stem Cell Transplantation

Go Itakura,
Yoshiomi Kobayashi,
Soraya Nishimura,
Hiroki Iwai,
Morito Takano,
Akio Iwanami,
Yoshiaki Toyama,
Hideyuki Okano,
Masaya Nakamura

Published: February 23, 2015
https://doi.org/10.1371/journal.pone.0116413

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Transplant rejection
Is the Subject Area "Transplant rejection" applicable to this article?

Thanks for your feedback.
Induced pluripotent stem cells
Is the Subject Area "Induced pluripotent stem cells" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Spinal cord
Is the Subject Area "Spinal cord" applicable to this article?

Thanks for your feedback.
Stem cell transplantation
Is the Subject Area "Stem cell transplantation" applicable to this article?

Thanks for your feedback.
Transplantation immunology
Is the Subject Area "Transplantation immunology" applicable to this article?

Thanks for your feedback.
Cell transplantation
Is the Subject Area "Cell transplantation" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.