Enhanced Amphiphilic Profile of a Short β-Stranded Peptide Improves Its Antimicrobial Activity

Giorgia Manzo; Mariano A. Scorciapino; Parvesh Wadhwani; Jochen Bürck; Nicola Pietro Montaldo; Manuela Pintus; Roberta Sanna; Mariano Casu; Andrea Giuliani; Giovanna Pirri; Vincenzo Luca; Anne S. Ulrich; Andrea C. Rinaldi

doi:10.1371/journal.pone.0116379

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Open Access

Peer-reviewed

Research Article

Enhanced Amphiphilic Profile of a Short β-Stranded Peptide Improves Its Antimicrobial Activity

Giorgia Manzo,

Affiliation Department of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato (CA), Italy
⨯
Mariano A. Scorciapino,

Affiliation Department of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato (CA), Italy
⨯
Parvesh Wadhwani,

Affiliation Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany
⨯
Jochen Bürck,

Affiliation Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany
⨯
Nicola Pietro Montaldo,

Affiliation Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato (CA), Italy
⨯
Manuela Pintus,

Affiliation Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato (CA), Italy
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Roberta Sanna,

Affiliation Department of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato (CA), Italy
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Mariano Casu,

Affiliation Department of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato (CA), Italy
⨯
Andrea Giuliani,

Affiliation Research & Development Unit, Spider Biotech S.r.l., I-10010 Colleretto Giacosa (TO), Italy
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Giovanna Pirri,

Affiliation Research & Development Unit, Spider Biotech S.r.l., I-10010 Colleretto Giacosa (TO), Italy
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Vincenzo Luca,

Affiliation Dipartimento di Scienze Biochimiche, “A. Rossi Fanelli”, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza Università di Roma, Rome, Italy
⨯
Anne S. Ulrich,

Affiliations Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany, Institute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany
⨯
Andrea C. Rinaldi

* E-mail: rinaldi@unica.it

Affiliation Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato (CA), Italy
⨯

Enhanced Amphiphilic Profile of a Short β-Stranded Peptide Improves Its Antimicrobial Activity

Giorgia Manzo,
Mariano A. Scorciapino,
Parvesh Wadhwani,
Jochen Bürck,
Nicola Pietro Montaldo,
Manuela Pintus,
Roberta Sanna,
Mariano Casu,
Andrea Giuliani,
Giovanna Pirri

Published: January 24, 2015
https://doi.org/10.1371/journal.pone.0116379

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