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Open Access
Peer-reviewed
Research Article
Variability in the Effect of 5-HTTLPR on Depression in a Large European Population: The Role of Age, Symptom Profile, Type and Intensity of Life Stressors
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Gabriella Juhasz ,
* E-mail: gabriella.juhasz@manchester.ac.uk
Affiliations Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary, MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary, Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, United Kingdom, and Manchester Academic Health Sciences Centre, Manchester, United Kingdom
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Xenia Gonda,
Affiliations Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary, MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary, Department of Clinical and Theoretical Mental Health, Kutvolgyi Clinical Center, Semmelweis University, Budapest, Hungary
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Gabor Hullam,
Affiliations MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary, Department of Measurement and Information Systems, Budapest University of Technology and Economics, Budapest, Hungary
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Nora Eszlari,
Affiliations Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary, MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary
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David Kovacs,
Affiliations Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary, MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary
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Judit Lazary,
Affiliation Department of Clinical and Theoretical Mental Health, Kutvolgyi Clinical Center, Semmelweis University, Budapest, Hungary
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Dorottya Pap,
Affiliations Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary, MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary
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Peter Petschner,
Affiliations Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary, MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary
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Rebecca Elliott,
Affiliation Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, United Kingdom, and Manchester Academic Health Sciences Centre, Manchester, United Kingdom
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John Francis William Deakin,
Affiliation Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, United Kingdom, and Manchester Academic Health Sciences Centre, Manchester, United Kingdom
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Ian Muir Anderson,
Affiliation Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, United Kingdom, and Manchester Academic Health Sciences Centre, Manchester, United Kingdom
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Peter Antal,
Affiliations MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary, Department of Measurement and Information Systems, Budapest University of Technology and Economics, Budapest, Hungary
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Klaus-Peter Lesch,
Affiliation Division of Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany, and Department of Translational Neuroscience, School of Mental Health and Neuroscience (MHENS), Maastricht University, Maastricht, The Netherlands
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Gyorgy Bagdy
Affiliations Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary, MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary
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Variability in the Effect of 5-HTTLPR on Depression in a Large European Population: The Role of Age, Symptom Profile, Type and Intensity of Life Stressors
- Gabriella Juhasz,
- Xenia Gonda,
- Gabor Hullam,
- Nora Eszlari,
- David Kovacs,
- Judit Lazary,
- Dorottya Pap,
- Peter Petschner,
- Rebecca Elliott,
- John Francis William Deakin
- Published: March 6, 2015
- https://doi.org/10.1371/journal.pone.0116316