Transcriptional Attenuation Controls Macrolide Inducible Efflux and Resistance in Streptococcus pneumoniae and in Other Gram-Positive Bacteria Containing mef/mel(msr(D)) Elements

Scott T. Chancey; Xianhe Bai; Nikhil Kumar; Elliott F. Drabek; Sean C. Daugherty; Thomas Colon; Sandra Ott; Naomi Sengamalay; Lisa Sadzewicz; Luke J. Tallon; Claire M. Fraser; Hervé Tettelin; David S. Stephens

doi:10.1371/journal.pone.0116254

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Peer-reviewed

Research Article

Transcriptional Attenuation Controls Macrolide Inducible Efflux and Resistance in Streptococcus pneumoniae and in Other Gram-Positive Bacteria Containing mef/mel(msr(D)) Elements

Scott T. Chancey,

Affiliations Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America, Laboratories of Microbial Pathogenesis, Department of Veterans Affairs Medical Center, Atlanta, Georgia, United States of America
⨯
Xianhe Bai,

Affiliations Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America, Laboratories of Microbial Pathogenesis, Department of Veterans Affairs Medical Center, Atlanta, Georgia, United States of America
⨯
Nikhil Kumar,

Affiliation Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Elliott F. Drabek,

Affiliation Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Sean C. Daugherty,

Affiliation Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Thomas Colon,

Affiliation Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Sandra Ott,

Affiliation Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Naomi Sengamalay,

Affiliation Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Lisa Sadzewicz,

Affiliation Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Luke J. Tallon,

Affiliation Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Claire M. Fraser,

Affiliations Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Hervé Tettelin,

Affiliations Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
David S. Stephens

* E-mail: dstep01@emory.edu

Affiliations Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America, Laboratories of Microbial Pathogenesis, Department of Veterans Affairs Medical Center, Atlanta, Georgia, United States of America
⨯

Transcriptional Attenuation Controls Macrolide Inducible Efflux and Resistance in Streptococcus pneumoniae and in Other Gram-Positive Bacteria Containing mef/mel(msr(D)) Elements

Scott T. Chancey,
Xianhe Bai,
Nikhil Kumar,
Elliott F. Drabek,
Sean C. Daugherty,
Thomas Colon,
Sandra Ott,
Naomi Sengamalay,
Lisa Sadzewicz,
Luke J. Tallon

Published: February 19, 2015
https://doi.org/10.1371/journal.pone.0116254

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