Involvement of the P2X7 Purinergic Receptor in Colonic Motor Dysfunction Associated with Bowel Inflammation in Rats

Luca Antonioli; Maria Cecilia Giron; Rocchina Colucci; Carolina Pellegrini; Deborah Sacco; Valentina Caputi; Genny Orso; Marco Tuccori; Carmelo Scarpignato; Corrado Blandizzi; Matteo Fornai

doi:10.1371/journal.pone.0116253

Loading metrics

Open Access

Peer-reviewed

Research Article

Involvement of the P2X7 Purinergic Receptor in Colonic Motor Dysfunction Associated with Bowel Inflammation in Rats

Luca Antonioli ,

Contributed equally to this work with: Luca Antonioli, Maria Cecilia Giron

Affiliation Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
⨯
Maria Cecilia Giron ,

Contributed equally to this work with: Luca Antonioli, Maria Cecilia Giron

Affiliation Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
⨯
Rocchina Colucci ,

* E-mail: r.colucci@med.unipi.it

Affiliation Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
⨯
Carolina Pellegrini,

Affiliation Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
⨯
Deborah Sacco,

Affiliation Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
⨯
Valentina Caputi,

Affiliation Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
⨯
Genny Orso,

Affiliation Scientific Institute IRCCS Eugenio Medea, Conegliano, Treviso, Italy
⨯
Marco Tuccori,

Affiliation Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
⨯
Carmelo Scarpignato,

Affiliation Laboratory of Clinical Pharmacology, University of Parma, Parma, Italy
⨯
Corrado Blandizzi,

Affiliation Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
⨯
Matteo Fornai

Affiliation Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
⨯

Involvement of the P2X7 Purinergic Receptor in Colonic Motor Dysfunction Associated with Bowel Inflammation in Rats

Luca Antonioli,
Maria Cecilia Giron,
Rocchina Colucci,
Carolina Pellegrini,
Deborah Sacco,
Valentina Caputi,
Genny Orso,
Marco Tuccori,
Carmelo Scarpignato,
Corrado Blandizzi

Published: December 30, 2014
https://doi.org/10.1371/journal.pone.0116253

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Colon
Is the Subject Area "Colon" applicable to this article?

Thanks for your feedback.
Colitis
Is the Subject Area "Colitis" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Immune receptors
Is the Subject Area "Immune receptors" applicable to this article?

Thanks for your feedback.
Muscle contraction
Is the Subject Area "Muscle contraction" applicable to this article?

Thanks for your feedback.
Functional electrical stimulation
Is the Subject Area "Functional electrical stimulation" applicable to this article?

Thanks for your feedback.
Carbachol
Is the Subject Area "Carbachol" applicable to this article?

Thanks for your feedback.
Inflammatory bowel disease
Is the Subject Area "Inflammatory bowel disease" applicable to this article?

Thanks for your feedback.