Two Novel α7 Nicotinic Acetylcholine Receptor Ligands: In Vitro Properties and Their Efficacy in Collagen-Induced Arthritis in Mice

Marjolein A. van Maanen; Roger L. Papke; Frieda A. Koopman; Jessica Koepke; Lisette Bevaart; Roger Clark; Diana Lamppu; Daniel Elbaum; Gregory J. LaRosa; Paul P. Tak; Margriet J. Vervoordeldonk

doi:10.1371/journal.pone.0116227

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Open Access

Peer-reviewed

Research Article

Two Novel α7 Nicotinic Acetylcholine Receptor Ligands: In Vitro Properties and Their Efficacy in Collagen-Induced Arthritis in Mice

Marjolein A. van Maanen,

Affiliation Department of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands
⨯
Roger L. Papke,

Affiliation Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida, United States of America
⨯
Frieda A. Koopman,

Affiliation Department of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands
⨯
Jessica Koepke,

Affiliations Department of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands, Arthrogen BV, Amsterdam, The Netherlands
⨯
Lisette Bevaart,

Affiliations Department of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands, Arthrogen BV, Amsterdam, The Netherlands
⨯
Roger Clark,

Affiliation Cornerstone Therapeutics, Inc., Cary, North Carolina, United States of America
⨯
Diana Lamppu,

Affiliation Cornerstone Therapeutics, Inc., Cary, North Carolina, United States of America
⨯
Daniel Elbaum,

Affiliation DEC Associates, LLC, Newton, Massachusetts, United States of America
⨯
Gregory J. LaRosa,

Affiliation Cornerstone Therapeutics, Inc., Cary, North Carolina, United States of America
⨯
Paul P. Tak,

Affiliation Department of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands
⨯
Margriet J. Vervoordeldonk

* E-mail: m.j.vervoordeldonk@amc.uva.nl

Affiliations Department of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands, Arthrogen BV, Amsterdam, The Netherlands
⨯

Two Novel α7 Nicotinic Acetylcholine Receptor Ligands: In Vitro Properties and Their Efficacy in Collagen-Induced Arthritis in Mice

Marjolein A. van Maanen,
Roger L. Papke,
Frieda A. Koopman,
Jessica Koepke,
Lisette Bevaart,
Roger Clark,
Diana Lamppu,
Daniel Elbaum,
Gregory J. LaRosa,
Paul P. Tak

Published: January 24, 2015
https://doi.org/10.1371/journal.pone.0116227

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Nicotinic acetylcholine receptors
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Arthritis
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Ion channels
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