A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

Shigeyuki Kon; Yosuke Nakayama; Naoki Matsumoto; Koyu Ito; Masashi Kanayama; Chiemi Kimura; Hitomi Kouro; Dai Ashitomi; Tadashi Matsuda; Toshimitsu Uede

doi:10.1371/journal.pone.0116210

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Research Article

A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

Shigeyuki Kon ,

* E-mail: kon@pharm.hokudai.ac.jp (SK); uedetoshimitsu@icloud.com (TU)

Affiliations Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
⨯
Yosuke Nakayama,

Affiliation Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
⨯
Naoki Matsumoto,

Affiliation Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
⨯
Koyu Ito,

Affiliation Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
⨯
Masashi Kanayama,

Affiliation Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
⨯
Chiemi Kimura,

Affiliation Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
⨯
Hitomi Kouro,

Affiliation Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
⨯
Dai Ashitomi,

Affiliation Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
⨯
Tadashi Matsuda,

Affiliation Department of Immunology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
⨯
Toshimitsu Uede

* E-mail: kon@pharm.hokudai.ac.jp (SK); uedetoshimitsu@icloud.com (TU)

Affiliation Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
⨯

A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

Shigeyuki Kon,
Yosuke Nakayama,
Naoki Matsumoto,
Koyu Ito,
Masashi Kanayama,
Chiemi Kimura,
Hitomi Kouro,
Dai Ashitomi,
Tadashi Matsuda,
Toshimitsu Uede

Published: December 29, 2014
https://doi.org/10.1371/journal.pone.0116210

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