Fomiroid A, a Novel Compound from the Mushroom Fomitopsis nigra, Inhibits NPC1L1-Mediated Cholesterol Uptake via a Mode of Action Distinct from That of Ezetimibe

• Tomohiro Chiba,

  Affiliations FANCL Research Institute, FANCL Corporation, 12-13 Kamishinano, Totsuka-ku, Kanagawa 244-0806, Japan, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan, Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan

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• Tsuyoshi Sakurada,

  Affiliation FANCL Research Institute, FANCL Corporation, 12-13 Kamishinano, Totsuka-ku, Kanagawa 244-0806, Japan

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• Rie Watanabe,

  Affiliation FANCL Research Institute, FANCL Corporation, 12-13 Kamishinano, Totsuka-ku, Kanagawa 244-0806, Japan

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• Kohji Yamaguchi,

  Affiliation FANCL Research Institute, FANCL Corporation, 12-13 Kamishinano, Totsuka-ku, Kanagawa 244-0806, Japan

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• Yasuhisa Kimura,

  Affiliation Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan

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• Noriyuki Kioka,

  Affiliation Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan

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• Hirokazu Kawagishi,

  Affiliations Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan, Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan, Graduate School of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan

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• Michinori Matsuo,

  Affiliations Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan, Department of Food and Nutrition, Kyoto Women's University, Kitahiyoshi-cho, Imakumano, Higashiyama-ku, Kyoto 605-8501, Japan

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• Kazumitsu Ueda

  * E-mail: uedak@kais.kyoto-u.ac.jp

  Affiliations Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan, Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan

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