Phosphoinositide-3 Kinase Inhibition Modulates Responses to Rhinovirus by Mechanisms that Are Predominantly Independent of Autophagy

Saila Ismail; Clare A. Stokes; Elizabeth C. Prestwich; Rebecca L. Roberts; Jatinder K. Juss; Ian Sabroe; Lisa C. Parker

doi:10.1371/journal.pone.0116055

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Peer-reviewed

Research Article

Phosphoinositide-3 Kinase Inhibition Modulates Responses to Rhinovirus by Mechanisms that Are Predominantly Independent of Autophagy

Saila Ismail ,

Current address: Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

¶SI and CAS are joint first authors on this work. IS and LCP are joint senior authors on this work.

Affiliation Academic Unit of Respiratory Medicine, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom
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Clare A. Stokes ,

¶SI and CAS are joint first authors on this work. IS and LCP are joint senior authors on this work.

Affiliation Academic Unit of Respiratory Medicine, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom
⨯
Elizabeth C. Prestwich,

Affiliation Academic Unit of Respiratory Medicine, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom
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Rebecca L. Roberts,

Affiliation Academic Unit of Respiratory Medicine, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom
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Jatinder K. Juss,

Affiliation Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospitals, Cambridge, CB2 2QQ, United Kingdom
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Ian Sabroe ,

¶SI and CAS are joint first authors on this work. IS and LCP are joint senior authors on this work.

Affiliation Academic Unit of Respiratory Medicine, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom
⨯
Lisa C. Parker

* E-mail: l.c.parker@sheffield.ac.uk

¶SI and CAS are joint first authors on this work. IS and LCP are joint senior authors on this work.

Affiliation Academic Unit of Respiratory Medicine, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom
⨯

Phosphoinositide-3 Kinase Inhibition Modulates Responses to Rhinovirus by Mechanisms that Are Predominantly Independent of Autophagy

Saila Ismail,
Clare A. Stokes,
Elizabeth C. Prestwich,
Rebecca L. Roberts,
Jatinder K. Juss,
Ian Sabroe,
Lisa C. Parker

Published: December 26, 2014
https://doi.org/10.1371/journal.pone.0116055

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Autophagic cell death
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Small interfering RNA
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Analysis of variance
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Rhinovirus infection
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