An Integrative Analysis of PIK3CA Mutation, PTEN, and INPP4B Expression in Terms of Trastuzumab Efficacy in HER2-Positive Breast Cancer

Aiko Sueta; Yutaka Yamamoto; Mutsuko Yamamoto-Ibusuki; Mitsuhiro Hayashi; Takashi Takeshita; Satoko Yamamoto; Hirotaka Iwase

doi:10.1371/journal.pone.0116054

Loading metrics

Open Access

Peer-reviewed

Research Article

An Integrative Analysis of PIK3CA Mutation, PTEN, and INPP4B Expression in Terms of Trastuzumab Efficacy in HER2-Positive Breast Cancer

Aiko Sueta,

Affiliations Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan, Department of Molecular-Targeting Therapy for Breast Cancer, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan
⨯
Yutaka Yamamoto ,

* E-mail: ys-yama@triton.ocn.ne.jp

Affiliations Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan, Department of Molecular-Targeting Therapy for Breast Cancer, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan
⨯
Mutsuko Yamamoto-Ibusuki,

Affiliation Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan
⨯
Mitsuhiro Hayashi,

Affiliation Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan
⨯
Takashi Takeshita,

Affiliation Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan
⨯
Satoko Yamamoto,

Affiliation Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan
⨯
Hirotaka Iwase

Affiliation Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan
⨯

An Integrative Analysis of PIK3CA Mutation, PTEN, and INPP4B Expression in Terms of Trastuzumab Efficacy in HER2-Positive Breast Cancer

Aiko Sueta,
Yutaka Yamamoto,
Mutsuko Yamamoto-Ibusuki,
Mitsuhiro Hayashi,
Takashi Takeshita,
Satoko Yamamoto,
Hirotaka Iwase

Published: December 26, 2014
https://doi.org/10.1371/journal.pone.0116054

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Polymerase chain reaction
Is the Subject Area "Polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Mutation detection
Is the Subject Area "Mutation detection" applicable to this article?

Thanks for your feedback.
Direct sequencing
Is the Subject Area "Direct sequencing" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.
Biomarkers
Is the Subject Area "Biomarkers" applicable to this article?

Thanks for your feedback.
Phosphatases
Is the Subject Area "Phosphatases" applicable to this article?

Thanks for your feedback.