Ubiquitous Transgene Expression of the Glucosylceramide-Synthesizing Enzyme Accelerates Glucosylceramide Accumulation and Storage Cells in a Gaucher Disease Mouse Model

Sonya Barnes; You-Hai Xu; Wujuan Zhang; Benjamin Liou; Kenneth D. R. Setchell; Liming Bao; Gregory A. Grabowski; Ying Sun

doi:10.1371/journal.pone.0116023

Loading metrics

Open Access

Peer-reviewed

Research Article

Ubiquitous Transgene Expression of the Glucosylceramide-Synthesizing Enzyme Accelerates Glucosylceramide Accumulation and Storage Cells in a Gaucher Disease Mouse Model

Sonya Barnes,

Affiliation The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
You-Hai Xu,

Affiliations The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Wujuan Zhang,

Affiliation The Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Benjamin Liou,

Affiliation The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯
Kenneth D. R. Setchell,

Affiliations The Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Liming Bao,

Affiliation Dartmouth-Hitchcock Medical Center, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, United States of America
⨯
Gregory A. Grabowski,

Affiliations The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Synageva BioPharma Corp., Lexington, Massachusetts, United States of America
⨯
Ying Sun

* E-mail: ying.sun@cchmc.org

Affiliations The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯

Ubiquitous Transgene Expression of the Glucosylceramide-Synthesizing Enzyme Accelerates Glucosylceramide Accumulation and Storage Cells in a Gaucher Disease Mouse Model

Sonya Barnes,
You-Hai Xu,
Wujuan Zhang,
Benjamin Liou,
Kenneth D. R. Setchell,
Liming Bao,
Gregory A. Grabowski,
Ying Sun

Published: December 31, 2014
https://doi.org/10.1371/journal.pone.0116023

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Gaucher's disease
Is the Subject Area "Gaucher's disease" applicable to this article?

Thanks for your feedback.
Spleen
Is the Subject Area "Spleen" applicable to this article?

Thanks for your feedback.
Animal models of disease
Is the Subject Area "Animal models of disease" applicable to this article?

Thanks for your feedback.
Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Phenotypes
Is the Subject Area "Phenotypes" applicable to this article?

Thanks for your feedback.