Interleukin-34 Restores Blood–Brain Barrier Integrity by Upregulating Tight Junction Proteins in Endothelial Cells

Shijie Jin; Yoshifumi Sonobe; Jun Kawanokuchi; Hiroshi Horiuchi; Yi Cheng; Yue Wang; Tetsuya Mizuno; Hideyuki Takeuchi; Akio Suzumura

doi:10.1371/journal.pone.0115981

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Open Access

Peer-reviewed

Research Article

Interleukin-34 Restores Blood–Brain Barrier Integrity by Upregulating Tight Junction Proteins in Endothelial Cells

Shijie Jin,

Affiliation Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
⨯
Yoshifumi Sonobe,

Affiliation Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
⨯
Jun Kawanokuchi,

Affiliation Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
⨯
Hiroshi Horiuchi,

Affiliation Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
⨯
Yi Cheng,

Affiliation Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
⨯
Yue Wang,

Affiliation Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
⨯
Tetsuya Mizuno,

Affiliation Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
⨯
Hideyuki Takeuchi ,

* E-mail: htake@riem.nagoya-u.ac.jp

Affiliation Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
⨯
Akio Suzumura

Affiliation Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan
⨯

Interleukin-34 Restores Blood–Brain Barrier Integrity by Upregulating Tight Junction Proteins in Endothelial Cells

Shijie Jin,
Yoshifumi Sonobe,
Jun Kawanokuchi,
Hiroshi Horiuchi,
Yi Cheng,
Yue Wang,
Tetsuya Mizuno,
Hideyuki Takeuchi,
Akio Suzumura

Published: December 23, 2014
https://doi.org/10.1371/journal.pone.0115981

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