Generation of a Nanobody Targeting the Paraflagellar Rod Protein of Trypanosomes

Emmanuel Obishakin; Benoit Stijlemans; Julien Santi-Rocca; Isabel Vandenberghe; Bart Devreese; Serge Muldermans; Philippe Bastin; Stefan Magez

doi:10.1371/journal.pone.0115893

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Research Article

Generation of a Nanobody Targeting the Paraflagellar Rod Protein of Trypanosomes

Emmanuel Obishakin ,

* E-mail: eobishak@vub.ac.be

Affiliations Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium, Structural Biology Research Center, VIB (Flanders Institute for Biotechnology), Pleinlaan 2, B-1050 Brussels, Belgium
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Benoit Stijlemans,

Affiliations Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium, Laboratory of Myeloid Cell Immunology, VIB, (Flanders Institute for Biotechnology) Pleinlaan 2, B-1050 Brussels, Belgium
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Julien Santi-Rocca,

Affiliation Trypanosome Cell Biology Unit, Institut Pasteur & CNRS, URA 2581, 25 rue du Docteur Roux, 75015 Paris, France
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Isabel Vandenberghe,

Affiliation Laboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Department of Biochemistry and Microbiology, Ghent University, K.L Ledeganckstraat 35, 9000, Ghent, Belgium
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Bart Devreese,

Affiliation Laboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Department of Biochemistry and Microbiology, Ghent University, K.L Ledeganckstraat 35, 9000, Ghent, Belgium
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Serge Muldermans,

Affiliations Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium, Structural Biology Research Center, VIB (Flanders Institute for Biotechnology), Pleinlaan 2, B-1050 Brussels, Belgium
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Philippe Bastin,

Affiliation Trypanosome Cell Biology Unit, Institut Pasteur & CNRS, URA 2581, 25 rue du Docteur Roux, 75015 Paris, France
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Stefan Magez

Affiliations Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium, Structural Biology Research Center, VIB (Flanders Institute for Biotechnology), Pleinlaan 2, B-1050 Brussels, Belgium
⨯

Generation of a Nanobody Targeting the Paraflagellar Rod Protein of Trypanosomes

Emmanuel Obishakin,
Benoit Stijlemans,
Julien Santi-Rocca,
Isabel Vandenberghe,
Bart Devreese,
Serge Muldermans,
Philippe Bastin,
Stefan Magez

Published: December 31, 2014
https://doi.org/10.1371/journal.pone.0115893

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Trypanosoma
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Enzyme-linked immunoassays
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Trypanosoma brucei gambiense
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Immunoprecipitation
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Antibodies
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Flagella
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Trypanosoma congolense
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