Influence of Genetic Variants in TPMT and COMT Associated with Cisplatin Induced Hearing Loss in Patients with Cancer: Two New Cohorts and a Meta-Analysis Reveal Significant Heterogeneity between Cohorts

• Melanie M. Hagleitner ,

  * E-mail: Melanie.Hagleitner@radboudumc.nl

  Affiliation Department of Pediatric Hematology and Oncology, Radboud University Medical Center, Nijmegen, The Netherlands

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• Marieke J. H. Coenen,

  Affiliation Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands

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• Ana Patino-Garcia,

  Affiliation Department of Pediatrics, University of Navarra and University Clinic, Pamplona, Spain

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• Eveline S. J. M. de Bont,

  Affiliation Department of Pediatric Hematology and Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• Anna Gonzalez-Neira,

  Affiliation Human Genotyping Unit-CeGen, Spanish National Cancer Research Center, Madrid, Spain

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• Hanneke I. Vos,

  Affiliation Department of Pediatric Hematology and Oncology, Radboud University Medical Center, Nijmegen, The Netherlands

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• Frank N. van Leeuwen,

  Affiliation Department of Pediatric Hematology and Oncology, Radboud University Medical Center, Nijmegen, The Netherlands

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• Hans Gelderblom,

  Affiliation Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands

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• Peter M. Hoogerbrugge,

  Affiliation Department of Pediatric Hematology and Oncology, Radboud University Medical Center, Nijmegen, The Netherlands

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• Henk-Jan Guchelaar,

  Affiliation Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands

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• Maroeska W. M. te Loo

  Affiliation Department of Pediatric Hematology and Oncology, Radboud University Medical Center, Nijmegen, The Netherlands

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