Identification of S100A9 as Biomarker of Responsiveness to the Methotrexate/Etanercept Combination in Rheumatoid Arthritis Using a Proteomic Approach

Antoine Obry; Thierry Lequerré; Julie Hardouin; Olivier Boyer; Patrice Fardellone; Peggy Philippe; Xavier Le Loët; Pascal Cosette; Olivier Vittecoq

doi:10.1371/journal.pone.0115800

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Open Access

Peer-reviewed

Research Article

Identification of S100A9 as Biomarker of Responsiveness to the Methotrexate/Etanercept Combination in Rheumatoid Arthritis Using a Proteomic Approach

Antoine Obry,

Affiliations INSERM, U905, Pathophysiology and Biotherapy of Inflammatory and Autoimmune Diseases, F-76000 Rouen, France, CNRS, UMR 6270, Polymers, Biopolymers and Surfaces, F-76821 Mont Saint Aignan, France, PISSARO Proteomics Facility, F-76821 Mont Saint Aignan, France, Normandy University, Institute of Research and Innovation in Biomedecine, F-76821 Mont Saint Aignan, France
⨯
Thierry Lequerré,

Affiliations INSERM, U905, Pathophysiology and Biotherapy of Inflammatory and Autoimmune Diseases, F-76000 Rouen, France, Normandy University, Institute of Research and Innovation in Biomedecine, F-76821 Mont Saint Aignan, France, Department of Rheumatology, Rouen University Hospital, F-76000 Rouen, France, INSERM, Centre d'investigation clinique 1404, F-76000 Rouen, France
⨯
Julie Hardouin,

Affiliations CNRS, UMR 6270, Polymers, Biopolymers and Surfaces, F-76821 Mont Saint Aignan, France, PISSARO Proteomics Facility, F-76821 Mont Saint Aignan, France, Normandy University, Institute of Research and Innovation in Biomedecine, F-76821 Mont Saint Aignan, France
⨯
Olivier Boyer,

Affiliations INSERM, U905, Pathophysiology and Biotherapy of Inflammatory and Autoimmune Diseases, F-76000 Rouen, France, Normandy University, Institute of Research and Innovation in Biomedecine, F-76821 Mont Saint Aignan, France, Department of Immunology, Rouen University Hospital, F-76000 Rouen, France
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Patrice Fardellone,

Affiliation Department of Rheumatology, Amiens University Hospital, F-80000 Amiens Cedex 1, France
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Peggy Philippe,

Affiliation of Rheumatology, University Hospital of Lille, F-59037 Lille Cedex, France
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Xavier Le Loët,

Affiliations INSERM, U905, Pathophysiology and Biotherapy of Inflammatory and Autoimmune Diseases, F-76000 Rouen, France, Normandy University, Institute of Research and Innovation in Biomedecine, F-76821 Mont Saint Aignan, France, Department of Rheumatology, Rouen University Hospital, F-76000 Rouen, France
⨯
Pascal Cosette ,

* E-mail: pascal.cosette@univ-rouen.fr

Affiliations CNRS, UMR 6270, Polymers, Biopolymers and Surfaces, F-76821 Mont Saint Aignan, France, PISSARO Proteomics Facility, F-76821 Mont Saint Aignan, France
⨯
Olivier Vittecoq

Affiliations INSERM, U905, Pathophysiology and Biotherapy of Inflammatory and Autoimmune Diseases, F-76000 Rouen, France, Normandy University, Institute of Research and Innovation in Biomedecine, F-76821 Mont Saint Aignan, France, Department of Rheumatology, Rouen University Hospital, F-76000 Rouen, France, INSERM, Centre d'investigation clinique 1404, F-76000 Rouen, France
⨯

Identification of S100A9 as Biomarker of Responsiveness to the Methotrexate/Etanercept Combination in Rheumatoid Arthritis Using a Proteomic Approach

Antoine Obry,
Thierry Lequerré,
Julie Hardouin,
Olivier Boyer,
Patrice Fardellone,
Peggy Philippe,
Xavier Le Loët,
Pascal Cosette,
Olivier Vittecoq

Published: December 29, 2014
https://doi.org/10.1371/journal.pone.0115800

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