Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1

Victoria L. Patterson; Alfred J. Zullo; Claire Koenig; Sean Stoessel; Hakryul Jo; Xinran Liu; Jinah Han; Murim Choi; Andrew T. DeWan; Jean-Leon Thomas; Chia-Yi Kuan; Josephine Hoh

doi:10.1371/journal.pone.0115789

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Open Access

Peer-reviewed

Research Article

Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1

Victoria L. Patterson,

Affiliation Department of Environmental Health Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Alfred J. Zullo,

Affiliation Department of Environmental Health Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Claire Koenig,

Affiliation Department of Environmental Health Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Sean Stoessel,

Affiliation Department of Environmental Health Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Hakryul Jo,

Affiliation Department of Environmental Health Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Xinran Liu,

Affiliation Center for Cellular and Molecular Imaging, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Jinah Han,

Affiliation Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Murim Choi,

Affiliation Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Andrew T. DeWan,

Affiliation Department of Chronic Disease Epidemiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Jean-Leon Thomas,

Affiliation Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Chia-Yi Kuan,

Affiliation Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, Georgia, United States of America
⨯
Josephine Hoh

* E-mail: josephine.hoh@yale.edu

Affiliation Department of Environmental Health Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯

Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1

Victoria L. Patterson,
Alfred J. Zullo,
Claire Koenig,
Sean Stoessel,
Hakryul Jo,
Xinran Liu,
Jinah Han,
Murim Choi,
Andrew T. DeWan,
Jean-Leon Thomas

Published: December 22, 2014
https://doi.org/10.1371/journal.pone.0115789

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